Contribution of creatine to protein homeostasis in athletes after endurance and sprint running

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• 作者：Fu-Chun Tang (1)
  Chun-Chen Chan (2)
  Po-Ling Kuo (1)
  
• 关键词：Purine metabolites ; Glutamine ; Alanine ; Hydroxyproline ; 3 ; Methylhistidine ; Urinary urea nitrogen
• 刊名：European Journal of Nutrition
• 出版年：2014
• 出版时间：February 2014
• 年：2014
• 卷：53
• 期：1
• 页码：61-71
• 全文大小：354 KB
• 作者单位：Fu-Chun Tang (1)
  Chun-Chen Chan (2)
  Po-Ling Kuo (1)
  
  1. Graduate Institute of Nutritional Sciences and Education, #162, Hoping E. Rd. 1st Sec, Taipei, 10600, Taiwan, ROC
  2. Department of Physical Education, National Taiwan Normal University, Taipei, Taiwan, ROC
  
• ISSN：1436-6215

文摘

Purpose Few studies have focused on the metabolic changes induced by creatine supplementation. This study investigated the effects of creatine supplementation on plasma and urinary metabolite changes of athletes after endurance and sprint running. Methods Twelve male athletes (20.3?±?1.4 y) performed two identical (65-0?% maximum heart rate reserved) 60?min running exercises (endurance trial) before and after creatine supplementation (12?g creatine monohydrate/day for 15?days), followed by a 5-day washout period. Subsequently, they performed two identical 100?m sprint running exercises (power trial) before and after 15?days of creatine supplementation in accordance with the supplementary protocol of the endurance trial. Body composition measurements were performed during the entire study. Plasma samples were examined for the concentrations of glucose, lactate, branched-chain amino acids (BCAAs), free-tryptophan (f-TRP), glutamine, alanine, hypoxanthine, and uric acid. Urinary samples were examined for the concentrations of hydroxyproline, 3-methylhistidine, urea nitrogen, and creatinine. Results Creatine supplementation significantly increased body weights of the athletes of endurance trial. Plasma lactate concentration and ratio of f-TRP/BCAAs after recovery from endurance running were significantly decreased with creatine supplementation. Plasma purine metabolites (the sum of hypoxanthine and uric acid), glutamine, urinary 3-methylhistidine, and urea nitrogen concentrations tended to decrease before running in trials with creatine supplements. After running, urinary hydroxyproline concentration significantly increased in the power trial with creatine supplements. Conclusions The findings suggest that creatine supplementation tended to decrease muscle glycogen and protein degradation, especially after endurance exercise. However, creatine supplementation might induce collagen proteolysis in athletes after sprint running.