Lactobacillus acidophilus attenuates Salmonella-induced intestinal inflammation via TGF-β signaling
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- 作者：I-Fei Huang ; I-Chun Lin ; Pei-Feng Liu ; Ming-Fang Cheng ; Yen-Chen Liu…
- 关键词：L. acidophilus ; Synbiotics ; Salmonella ; TGF ; b ; NF ; κB ; MIR21 ; SMAD
- 刊名：BMC Microbiology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：15
- 期：1
- 全文大小：1,028 KB
- 刊物主题：Microbiology; Biological Microscopy; Fungus Genetics; Parasitology; Virology; Life Sciences, general;
- 出版者：BioMed Central
- ISSN：1471-2180
文摘
Background Salmonella is a common intestinal pathogen that causes acute and chronic inflammatory response. Probiotics reduce inflammatory cytokine production and serve as beneficial commensal microorganisms in the human gastrointestinal tract. TGF-β (transforming growth factor β)/SMAD and NF-κB signaling play important roles in inflammation in intestinal cells. However, the involvement of the signaling in regulating inflammation between Salmonella and probiotics is not fully understood.