Validation and application of health utilities index in Chinese subjects with down syndrome

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• 作者：Winnie Ka Yan Mok (1)
  Wilfred Hing-Sang Wong (1)
  Gary Tsz Kin Mok (1)
  Yoyo Wing Yiu Chu (1)
  Frederick Ka Wing Ho (1)
  Chun Bong Chow (1)
  Patrick Ip (1)
  Brian Hon-Yin Chung (1)
  
  1. Department of Paediatrics and Adolescent Medicine ; Queen Mary Hospital ; Li Ka Shing Faculty of Medicine ; The University of Hong Kong ; Hong Kong Special Administrative Region ; People鈥檚 Republic of China
  
• 关键词：Down syndrome ; Health ; related Quality of Life ; Health Utility Index ; Chinese ; Chronic health conditions
• 刊名：Health and Quality of Life Outcomes
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：12
• 期：1
• 全文大小：562 KB
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• 刊物主题：Quality of Life Research; Quality of Life Research;
• 出版者：BioMed Central
• ISSN：1477-7525

文摘

Objectives The objectives of the study were (1) to validate the Chinese version of Health Utilities Index (HUI-Ch); (2) to examine the Health-related Quality of Life (HRQoL) of Chinese subjects with Down syndrome (DS); and (3) to study the impact of chronic health conditions on HRQoL of Chinese with DS. Methods The multiple choice questionnaire for scoring Health Utilities Index Mark 2 (HUI2) and Health Utilities Index Mark 3 (HUI3) was translated and validated. In addition to the HRQoL scores from HUI2 and HUI3, proxy-data on socio-demographics, and 10 common chronic health conditions for people with DS were collected and analyzed. Data analysis involves multiple imputation and multiple regression analysis to predict variations in HRQoL in relation to different factors. Lastly, a gradient interval was constructed on the number of chronic health conditions in relation to HRQoL. Results HUI-Ch was validated according to standard guidelines. People with DS were found to have a lower HRQoL as compared to the general population, with the majority categorized as moderate or severe on the scale. Behavioral and hearing problems on HUI2, and hearing problems on HUI3 were found to be statistically significant predictors of a lower HRQoL score. A significant gradient relationship existed showing when the number of health problems increased, the HRQoL scores decreased. Conclusions HUI-Ch is a valid instrument to assess HRQoL. It can have broad application in Chinese subjects with DS including the study of the impact of different chronic health conditions on their quality of life. The quantifiable nature of HUI-Ch will facilitate longitudinal study on the well-being of subjects with DS and evaluation of effectiveness of intervention programs in the near future.