Hepatic involvement of Langerhans cell histiocytosis in children—imaging findings of computed tomography, magnetic resonance imaging and magnetic resonance cholangiopancreatography

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• 作者：Yingyan Shi (1)
  Zhongwei Qiao (1)
  Chunmei Xia (2)
  Ying Gong (1)
  Haowei Yang (1)
  Guoping Li (1)
  Mier Pa (1)
  
• 关键词：Langerhans cell histiocytosis ; Hepatic bile duct ; Computed tomography ; Magnetic resonance imaging ; Magnetic resonance cholangiopancreatography ; Liver ; Children
• 刊名：Pediatric Radiology
• 出版年：2014
• 出版时间：June 2014
• 年：2014
• 卷：44
• 期：6
• 页码：713-718
• 全文大小：
• 参考文献：1. Schmidt S, Eich G, Geoffray A et al (2008) Extraosseous Langerhans cell histiocytosis in children. Radiographics 28:707-26, quiz 910-11 CrossRef
  2. Weitzman S, Egeler RM (2008) Langerhans cell histiocytosis: update for the pediatrician. Curr Opin Pediatr 20:23-9 CrossRef
  3. Schmidt S, Eich G, Hanquinet S et al (2004) Extra-osseous involvement of Langerhans-cell histiocytosis in children. Pediatr Radiol 34:313-21 CrossRef
  4. Abdallah M, Genereau T, Donadieu J et al (2011) Langerhans-cell histiocytosis of the liver in adults. Clin Res Hepatol Gastroenterol 35:475-81 CrossRef
  5. Chan YL, Li CK, Lee CY (1997) Sonographic appearance of hepatic Langerhans cell histiocytosis. Clin Radiol 52:761-63 CrossRef
  6. Chaudhary A, Debnath J, Thulkar S et al (2006) Imaging findings in hepatic Langerhans-cell histiocytosis. Indian J Pediatr 73:1036-038 CrossRef
  7. Kilborn TN, Teh J, Goodman TR (2003) Paediatric manifestations of Langerhans cell histiocytosis: a review of the clinical and radiological findings. Clin Radiol 58:269-78 CrossRef
  8. Kim M, Lyu C, Jin Y et al (1999) Langerhans-cell histiocytosis as a cause of periportal abnormal signal intensity on MRI. Abdom Imaging 24:373-77 CrossRef
  9. Radin DR (1992) Langerhans cell histiocytosis of the liver: imaging findings. AJR Am J Roentgenol 159:63-4 CrossRef
  10. Arakawa A, Matsukawa T, Yamashita Y et al (1994) Periportal fibrosis in Langerhans-cell histiocytosis mimicking multiple liver tumors: US, CT, and MR findings. J Comput Assist Tomogr 18:157-59 CrossRef
  11. Wong A, Ortiz-Neira CL, Reslan WA et al (2006) Liver involvement in Langerhans cell histiocytosis. Pediatr Radiol 36:1105-107 CrossRef
  12. Caruso S, Miraglia R, Maruzzelli L et al (2008) Biliary wall calcification in Langerhans cell histiocytosis: report of two cases. Pediatr Radiol 38:791-94 CrossRef
  13. Kaplan KJ, Goodman ZD, Ishak KG (1999) Liver involvement in Langerhans-cell histiocytosis: a study of nine cases. Mod Pathol 12:370-78
  14. Meyer JS, De Camargo B (1998) The role of radiology in the diagnosis and follow-up of Langerhans cell histiocytosis. Hematol Oncol Clin N Am 12:307-26 CrossRef
  15. Jaffe R (2004) Liver involvement in the histiocytic disorders of childhood. Pediatr Dev Pathol 7:214-25
  16. Ito K, Mitchell DG, Outwater EK et al (1999) Primary sclerosing cholangitis: MR imaging features. AJR Am J Roentgenol 172:1527-533 CrossRef
  17. Konig CW, Pfannenberg C, Trubenbach J et al (2001) MR cholangiography in the diagnosis of sclerosing cholangitis in Langerhans-cell histiocytosis. Eur Radiol 11:2516-520 CrossRef
  18. Siegel MJ, Herman TE (1992) Periportal low attenuation at CT in childhood. Radiology 183:685-88
  19. Braier J, Ciocca M, Latella A et al (2002) Cholestasis, sclerosing cholangitis, and liver transplantation in Langerhans cell Histiocytosis. Med Pediatr Oncol 38:178-82 CrossRef
  20. Textor HJ, Flacke S, Pauleit D et al (2002) Three-dimensional magnetic resonance cholangiopancreatography with respiratory triggering in the diagnosis of primary sclerosing cholangitis: comparison with endoscopic retrograde cholangiography. Endoscopy 34:984-90 CrossRef
  21. Heyn RM, Hamoudi A, Newton WA Jr (1990) Pretreatment liver biopsy in 20 children with histiocytosis X: a clinicopathologic correlation. Med Pediatr Oncol 18:110-18 CrossRef
  22. Mampaey S, Warson F, Van Hedent E et al (1999) Imaging findings in Langerhans-cell histiocytosis of the liver and the spleen in an adult. Eur Radiol 9:96-8 CrossRef
  
• 作者单位：Yingyan Shi (1)
  Zhongwei Qiao (1)
  Chunmei Xia (2)
  Ying Gong (1)
  Haowei Yang (1)
  Guoping Li (1)
  Mier Pa (1)
  
  1. Department of Radiology, Children’s Hospital of Fudan University, 399 Wanyuan Road, Minhang District, Shanghai, 201102, People’s Republic of China
  2. Physiology and Pathophysiology Department, Shanghai Medical College of Fudan University, 130 Dongan Road, Xuhui District, Shanghai, 200032, People’s Republic of China
  
• ISSN：1432-1998

文摘

Background Langerhans cell histiocytosis is a rare disease that occurs mainly in children, and hepatic involvement is generally a poor prognostic factor. Objective To describe CT and MRI findings of hepatic involvement of Langerhans cell histiocytosis in children, especially the abnormal bile duct manifestation on magnetic resonance cholangiopancreatography (MRCP). Materials and methods Thirteen children (seven boys, six girls; mean age 28.9?months) were diagnosed with disseminated Langerhans cell histiocytosis. They underwent CT (n--) or MRI (n--), or CT and MRI examinations (n--) to evaluate the liver involvement. Results Periportal abnormalities presented as band-like or nodular lesions on CT and MRI in all 13 children. The hepatic parenchymal lesions were found in the peripheral regions of the liver in seven children, including multiple nodules on MRI (n--), and cystic-like lesions on CT and MRI (n--). In 11 of the 13 children the dilatations of the bile ducts were observed on CT and MRI. Eight of the 13 children underwent MR cholangiopancreatography, which demonstrated stenoses or segmental stenoses with slight dilatation of the central bile ducts, including the common hepatic duct and its first-order branches. The peripheral bile ducts in these children showed segmental dilatations and stenoses. Conclusion Stenosis of the central bile ducts revealed by MR cholangiopancreatography was the most significant finding of liver involvement in Langerhans cell histiocytosis in children.