Cilia in autophagy and cancer

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• 作者：Muqing Cao ; Qing Zhong
• 关键词：Cilia ; Cell cycle ; Cilia ; related signaling ; Autophagy ; Cancer
• 刊名：Cilia
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：5
• 期：1
• 全文大小：1,013 KB
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• 作者单位：Muqing Cao (1)
  Qing Zhong (1)
  
  1. Center for Autophagy Research; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
  
• 刊物主题：Cell Biology; Developmental Biology; Human Genetics; Molecular Medicine; Biochemistry, general; Receptors;
• 出版者：BioMed Central
• ISSN：2046-2530

文摘

Cancer cells are distinguished from normal cells by increased proliferation and metabolism, loss of polarity control, and the potential to invade other tissues of the body. As hubs of signaling transduction, primary cilia have been linked to diverse developmental and degenerative disorders. Interestingly, loss of cilia has been observed in multiple malignant tumors, suggesting a potential suppressive role of cilia in cancer development. More recently, emerging studies began to unveil the bidirectional interaction of cilia and autophagy, a basic cellular clearance and recycling mechanism to regulate cell homeostasis. Here, we summarize the interplay between cilia and autophagy and discuss the roles of cilia in both autophagy and cancer. Keywords Cilia Cell cycle Cilia-related signaling Autophagy Cancer