Interaction of Citrus Juices with Cyclosporine: Systematic Review and Meta-Analysis

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• 作者：Kannan Sridharan ; Gowri Sivaramakrishnan
• 刊名：European Journal of Drug Metabolism and Pharmacokinetics
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：41
• 期：6
• 页码：665-673
• 全文大小：
• 刊物主题：Pharmacology/Toxicology; Pharmacy; Human Physiology; Pharmaceutical Sciences/Technology; Medical Biochemistry;
• 出版者：Springer International Publishing
• ISSN：2107-0180
• 卷排序：41

文摘

IntroductionCyclosporine is an immunosuppressant with narrow therapeutic window, metabolized mainly by cytochrome P450 3A4 (CYP3A4) and minimally by cytochrome P450 3A5 (CYP3A5). Citrus juices such as grapefruit juice (GFJ), orange, lemon, pomelo and lime were known to interact with cyclosporine in several randomized controlled trials. The present review is a systematic compilation and quantitative synthesis on the changes of cyclosporine pharmacokinetics with concomitant citrus juice administration.