Evaluation of a questionnaire to assess selected infectious diseases and their risk factors
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- 作者：Claudia Sievers (1)
Manas K. Akmatov (1)
Lothar Kreienbrock (2)
Katja Hille (2)
Wolfgang Ahrens (3) (4)
Kathrin Günther (3)
Dieter Flesch-Janys (5)
Nadia Obi (5)
Karin B. Michels (6) (7)
Julia Fricke (8) (9)
Karin H. Greiser (8)
Rudolf Kaaks (8)
Hans-Hartmut Peter (10)
Frank Pessler (11) (12)
Alexandra Nieters (10)
Gérard Krause (1) (13) - 关键词：Survey validity ; Infections ; Questionnaires ; Self ; report ; German National Cohort (GNC) ; Infektionen ; Fragebogen zu Infektionskrankheiten ; Selbsteinsch?tzung ; Validierung ; Nationale Kohorte (NaKo)
- 刊名：Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz
- 出版年：2014
- 出版时间：November 2014
- 年：2014
- 卷：57
- 期：11
- 页码：1283-1291
- 全文大小：530 KB
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Manas K. Akmatov (1)
Lothar Kreienbrock (2)
Katja Hille (2)
Wolfgang Ahrens (3) (4)
Kathrin Günther (3)
Dieter Flesch-Janys (5)
Nadia Obi (5)
Karin B. Michels (6) (7)
Julia Fricke (8) (9)
Karin H. Greiser (8)
Rudolf Kaaks (8)
Hans-Hartmut Peter (10)
Frank Pessler (11) (12)
Alexandra Nieters (10)
Gérard Krause (1) (13)
1. Department of Epidemiology, Helmholtz Centre for Infection Research, Inhoffenstra?e 7, 38124, Braunschweig, Germany
2. Department of Biometry, Epidemiology and Information Processing, WHO Collaborating Centre for Research and Training in Veterinary Public Health, University of Veterinary Medicine Hannover, Hannover, Germany
3. Leibniz Institute for Prevention Research and Epidemiology—BIPS, Bremen, Germany
4. Institute for Statistics, Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany
5. Department of Cancer Epidemiology, Clinical Cancer Registry, University Cancer Center Hamburg (UCCH), Hamburg, Germany
6. Institute for Prevention and Cancer Epidemiology, University Medical Center Freiburg, Freiburg, Germany
7. Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics and Gynecology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
8. Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
9. Institute for Social Medicine, Epidemiology and Health Economics, Charité- Universit?tsmedizin Berlin, Berlin, Germany
10. Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany
11. Institute for Experimental Infection Research, TWINCORE Center for Experimental and Clinical Infection Research, Hannover, Germany
12. Helmholtz Centre for Infection Research, Braunschweig, Germany
13. Hanover Medical School, Hannover, Germany - ISSN：1437-1588
文摘
Background/objectives The risk to die from an infectious disease in Germany has been continuously decreasing over the last century. Since infections are, however, not only causes of death but risk factors for diseases like cardiovascular diseases, it is essential to monitor and analyze their prevalence and frequency, especially in consideration of the increased life expectancy. To gain more knowledge about infectious diseases as risk factors and their implications on the condition and change of the immune status, the German National Cohort (GNC), a population-based prospective cohort study, will recruit 200,000 subjects between 2014 and 2017. In Pretest?1, a feasibility study for the GNC, we evaluated a self-administered and self-report questionnaire on infectious diseases and on the use of health care facilities (hereinafter called “ID Screen- for feasibility and validity. Methods From August–November 2011, 435?participants between the ages of 20-9 completed the ID Screen. All subjects had been recruited via a random sample from the local residents-registration offices by 4?of the 18?participating study centers. The questionnaire encompasses 77 variables in six sections assessing items such as 12-month prevalence of infections, cumulative prevalence of infectious diseases, visit of health care facilities and vaccination. The feasibility was amongst others evaluated by assessing the completeness and comprehensiveness of the questionnaire. To assess the questionnaires ability to measure “immune status-and “susceptibility to infections- multivariate analysis was used. Results The overall practicability was good and most items were well understood, demonstrated by -- of missing values. However, direct comparison of the items 12-month prevalence and lifetime prevalence of nephritis/pyelitis showed poor agreement and thereby poor understanding by 80-?of the participants, illustrating the necessity for a clear, lay person appropriate description of rare diseases to increase comprehensibility. The questionnaire will be used to support the assessment of immune dysfunction and frequency of infection. An analysis of these constructs in an exploratory factor analysis revealed limited applicability due to low interitem correlation (Cronbach’s α--.5). This is corroborated by the extraction of more than one factor with a Kaiser–Meyer–Olkin measure of 0.6 instead of a unidimensional latent construct for “immune status- Conclusion All in all, the ID Screen is a good and reliable tool to measure infectious diseases as risk factors and outcome in general, but requires a better translation of infection specific terms into lay person terms. For the assessment of the overall immune status, the tool has strong limitations. Vaccinations status should also rather be assessed based on vaccination certificates than on participants-recall.