Pathology of perinatal brain damage: background and oxidative stress markers

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• 作者：Gabriele Tonni (1)
  Silvia Leoncini (2) (3)
  Cinzia Signorini (2)
  Lucia Ciccoli (2)
  Claudio De Felice (4)
  
• 关键词：Birth asphyxia ; Perinatal brain damage ; Cerebral palsy ; Electronic fetal monitoring ; Oxidative stress
• 刊名：Archives of Gynecology and Obstetrics
• 出版年：2014
• 出版时间：July 2014
• 年：2014
• 卷：290
• 期：1
• 页码：13-20
• 全文大小：
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• 作者单位：Gabriele Tonni (1)
  Silvia Leoncini (2) (3)
  Cinzia Signorini (2)
  Lucia Ciccoli (2)
  Claudio De Felice (4)
  
  1. Prenatal Diagnostic Service, Guastalla Civil Hospital, AUSL Reggio Emilia, Via Donatori Sangue, 1, 42016, Guastalla, Reggio Emilia, Italy
  2. Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy
  3. Child Neuropsychiatry Unit, University Hospital Azienda Ospedaliera Universitaria Senese (AOUS), Siena, Italy
  4. Neonatal Intensive Care Unit, University Hospital Azienda Ospedaliera Universitaria Senese AOUS, Siena, Italy
  
• ISSN：1432-0711

文摘

Purpose To review historical scientific background and new perspective on the pathology of perinatal brain damage. The relationship between birth asphyxia and subsequent cerebral palsy has been extensively investigated. The role of new and promising clinical markers of oxidative stress (OS) is presented. Methods Electronic search of PubMed-Medline/EMBASE database has been performed. Laboratory and clinical data involving case series from the research group are reported. Results The neuropathology of birth asphyxia and subsequent perinatal brain damage as well as the role of electronic fetal monitoring are reported following a review of the medical literature. Conclusions This review focuses on OS mechanisms underlying the neonatal brain damage and provides different perspective on the most reliable OS markers during the perinatal period. In particular, prior research work on neurodevelopmental diseases, such as Rett syndrome, suggests the measurement of oxidized fatty acid molecules (i.e., F4-Neuroprostanes and F2-Dihomo-Isoprostanes) closely related to brain white and gray matter oxidative damage.