Exploring neurodevelopmental outcome measures used in children with cerebral malaria: the perspectives of caregivers and health workers in Malawi

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• 作者：Emmie W. Mbale ; Terrie Taylor ; Bernard Brabin ; Macpherson Mallewa…
• 关键词：Cerebral malaria ; Neurodevelopment ; Core outcomes ; Clinical outcomes ; Neurodisability ; Africa ; Qualitative ; Interviews ; Family perspectives ; Child disability
• 刊名：BMC Pediatrics
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：17
• 期：1
• 全文大小：611KB
• 刊物主题：Pediatrics; Internal Medicine;
• 出版者：BioMed Central
• ISSN：1471-2431
• 卷排序：17

文摘

BackgroundProgress has been made in tackling malaria however there are still over 207 million cases worldwide, the majority in children. As survival rates improve, numbers of children with long-term neurodisabling sequelae are likely to increase. Most outcome studies in cerebral malaria (CM) have focused only on body function and structure and less on outcomes within the broader framework of the International Classification of Functioning and Disability (ICF). The aim of this study was to utilise qualitative methods to identify relevant clinical outcomes in CM to support formulation of a core outcome set relevant to CM and other acquired brain injuries for use in future clinical trials.