Influence of the serum levels of immunoglobulins on clinical outcomes in medical intensive-care patients

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• 作者：C. Geier ; J. Schröder ; A. Tamm ; S. Dietz…
• 关键词：Immunoglobulins ; Immune system ; Intensive care ; Clinical outcome ; Sepsis ; Mortality
• 刊名：Medizinische Klinik - Intensivmedizin und Notfallmedizin
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：112
• 期：1
• 页码：30-37
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Intensive / Critical Care Medicine; Emergency Medicine; Internal Medicine;
• 出版者：Springer Medizin
• ISSN：2193-6226
• 卷排序：112

文摘

IntroductionEndogenous immunoglobulins (Igs) are of fundamental importance in the host defense after microbial infections. However, the therapeutic administration of intravenous IgG (IVIgG) has not yet been shown to improve clinical outcomes in patients suffering from sepsis, and in the case of IgM-containing preparations (IVIgGMA) the positive evidence is only weak. Recently published studies implicate that Ig levels on admission could have an impact on the patient’s response to IVIg treatment and on outcomes of critically ill patients.