Proteomics progresses in microbial physiology and clinical antimicrobial therapy

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• 作者：B. Chen ; D. Zhang ; X. Wang ; W. Ma ; S. DengR30
• 刊名：European Journal of Clinical Microbiology & Infectious Diseases
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：36
• 期：3
• 页码：403-413
• 全文大小：1013KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Medical Microbiology; Internal Medicine;
• 出版者：Springer Berlin Heidelberg
• ISSN：1435-4373
• 卷排序：36

文摘

Clinical microbial identification plays an important role in optimizing the management of infectious diseases and provides diagnostic and therapeutic support for clinical management. Microbial proteomic research is aimed at identifying proteins associated with microbial activity, which has facilitated the discovery of microbial physiology changes and host–pathogen interactions during bacterial infection and antimicrobial therapy. Here, we summarize proteomic-driven progresses of host–microbial pathogen interactions at multiple levels, mass spectrometry-based microbial proteome identification for clinical diagnosis, and antimicrobial therapy. Proteomic technique progresses pave new ways towards effective prevention and drug discovery for microbial-induced infectious diseases.