Cleft lip and palate transmembrane protein 1 rs31489 polymorphism is associated with lung cancer risk: a meta-analysis

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• 作者：Yuansheng Zang (1)
  Wei Nie (1)
  Zheng Fang (1)
  Bing Li (1)
  
• 关键词：Lung cancer ; CLPTM1L ; Meta ; analysis ; Polymorphism
• 刊名：Tumor Biology
• 出版年：2014
• 出版时间：June 2014
• 年：2014
• 卷：35
• 期：6
• 页码：5583-5588
• 全文大小：
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• 作者单位：Yuansheng Zang (1)
  Wei Nie (1)
  Zheng Fang (1)
  Bing Li (1)
  
  1. Department of Respiratory Medicine, Shanghai Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, 200003, China
  
• ISSN：1423-0380

文摘

The potentially functional polymorphism, rs31489, in the promoter region of cleft lip and palate transmembrane protein 1 (CLPTM1L) gene has been implicated in cancer risk. However, individual published studies showed inconclusive results. To obtain a more precise estimate of the association between CLPTM1L rs31489 and risk of lung cancer, we performed a meta-analysis. Summary odds ratios (ORs) and corresponding 95?% confidence intervals (CIs) were estimated using random-effects models. Ten individual case–control studies in eight publications with 20,680 cases and 28,330 controls were included. Overall, the variant genotypes were associated with a significantly increased lung cancer risk in different genetic models (CC + AC vs. AA: OR--.20, 95?% CI 1.12-.28, P-lt;-.001; CC vs. AC + AA: OR--.15, 95?% CI 1.07-.23, P-lt;-.001; CC vs. AA: OR--.28, 95?% CI 1.17-.41, P-lt;-.001; CC vs. AC: OR--.11, 95?% CI 1.05-.17, P-lt;-.001; C vs. A: OR--.12, 95?% CI 1.06-.18, P-lt;-.001). In the stratified analyses, the increased lung risk remained for the studies of Caucasian populations. In conclusion, this meta-analysis suggested that CLPTM1L rs31489 was a potential biomarker for lung cancer risk in Caucasians.