Genetic polymorphisms of TERT and CLPTM1L, cooking oil fume exposure, and risk of lung cancer: a case–control study in a Chinese non-smoking female population

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• 作者：Zhihua Yin (1) (2)
  Zhigang Cui (3)
  Yangwu Ren (1) (2)
  Haibo Zhang (4)
  Ying Yan (4)
  Yuxia Zhao (5)
  Rui Ma (6)
  Qianqian Wang (1) (2)
  Qincheng He (3)
  Baosen Zhou (1) (2)
  
• 关键词：TERT gene ; CLPTM1L gene ; Single nucleotide polymorphism ; Lung cancer ; Non ; smoker
• 刊名：Medical Oncology
• 出版年：2014
• 出版时间：August 2014
• 年：2014
• 卷：31
• 期：8
• 全文大小：190 KB
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• 作者单位：Zhihua Yin (1) (2)
  Zhigang Cui (3)
  Yangwu Ren (1) (2)
  Haibo Zhang (4)
  Ying Yan (4)
  Yuxia Zhao (5)
  Rui Ma (6)
  Qianqian Wang (1) (2)
  Qincheng He (3)
  Baosen Zhou (1) (2)
  
  1. Department of Epidemiology, School of Public Health, China Medical University, Shenyang, 110001, People’s Republic of China
  2. Key Laboratory of Cancer Etiology and Intervention (China Medical University), Liaoning Provincial Department of Education, Liaoning, People’s Republic of China
  3. China Medical University, Shenyang, 110001, China
  4. Department of Radiotherapy, Shenyang Northern Hospital, Shenyang, 110001, People’s Republic of China
  5. Department of Radiation Oncology, Fourth Affiliated Hospital of China Medical University, Shenyang, 110001, People’s Republic of China
  6. Department of Internal Medicine, Liaoning Cancer Hospital & Institute, Shenyang, 110001, People’s Republic of China
  
• ISSN：1559-131X

文摘

Genetic polymorphisms of telomerase reverse transcriptase (TERT) and cleft lip and palate transmembrane 1-like (CLPTM1L) genes in chromosome 5p15.33 region were previously identified to influence the risks of lung cancer. This study aimed to investigate the association between polymorphisms in TERT and CLPTM1L genes with the risk of lung cancer, as well as the interaction of the polymorphisms and the environmental risk factors in Chinese non-smoking females. A hospital-based case–control study of 524 cases and 524 controls was conducted. Two polymorphisms were determined by Taqman allelic discrimination method. The statistical analyses were performed mostly with SPSS. This study showed that the individuals with the TG or GG genotypes of TERT polymorphism (rs2736100) were at an increased risk for lung cancer compared with those carrying the TT genotype in Chinese non-smoking females [adjusted odds ratios (ORs) were 1.44 and 1.85, 95?% confidence intervals (CIs) were 1.09-.90 and 1.29-.65, respectively]. The stratified analysis suggested that increased risks were more pronounced in lung adenocarcinoma (corresponding ORs were 1.71 and 2.30, 95?% CIs were 1.25-.35 and 1.54-.43). Our results showed that exposure to cooking oil fume was associated with increased risk of lung cancer in Chinese non-smoking females (adjusted ORs 1.59, 95?%?CI 1.13-.23). However, we did not observe a significant interaction of cooking oil fume and TERT polymorphism on lung cancer among Chinese non-smoking females. TERT polymorphism (rs2736100) might be a genetic susceptibility factor for lung cancer in non-smoking females in China.