Correlation of CLPTM1L polymorphisms with lung cancer susceptibility and response to cisplatin-based chemotherapy in a Chinese Han population

详细信息    查看全文

• 作者：Yiqian Liang ; Asmitananda Thakur ; Lei Gao ; Ting Wang ; Shuo Zhang ; Hui Ren…
• 关键词：Lung cancer ; Single nucleotide polymorphism ; CLPTM1L ; Susceptibility ; Chemotherapy
• 刊名：Tumor Biology
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：35
• 期：12
• 页码：12075-12082
• 全文大小：179 KB
• 参考文献：1. Smith RA, Cokkinides V, Brooks D, Saslow D, Shah M, Brawley OW. Cancer screening in the United States, 2011: a review of current American Cancer Society guidelines and issues in cancer screening. CA Cancer J Clin. 2011;61:8-0. CrossRef
  2. Pirozynski M. 100 years of lung cancer. Respir Med. 2006;100:2073-4. CrossRef
  3. Chen WQ, Zeng HM, Zheng RS, Zhang SW, He J. Cancer incidence and mortality in China. Chin J Cancer Res. 2007;24:1-. CrossRef
  4. Chen WQ, Zhang SW, Zou XN. Evaluation on the incidence, mortality and tendency of lung cancer in China. Thorac Cancer. 2010;1:35-0. CrossRef
  5. Shields PG. Molecular epidemiology of smoking and lung cancer. Oncogene. 2002;21:6870-. CrossRef
  6. Lichtenstein P, Holm NV, Verkasalo PK, Iliadou A, Kaprio J, Koskenvuo M, et al. Environmental and heritable factors in the causation of cancer—analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med. 2000;343:78-5. CrossRef
  7. D’Addario G, Pintilie M, Leighl NB, Feld R, Cerny T, Shepherd FA. Platinum-based versus non-platinum-based chemotherapy in advanced non-small-cell lung cancer: a meta-analysis of the published literature. J Clin Oncol. 2005;23:2926-6. CrossRef
  8. Chang A. Chemotherapy, chemoresistance and the changing treatment landscape for NSCLC. Lung Cancer. 2011;71:3-0. CrossRef
  9. Seng KC, Seng CK. The success of the genome-wide association approach: a brief story of a long struggle. Eur J Hum Genet. 2008;16:554-4. CrossRef
  10. McKay JD, Hung RJ, Gaborieau V, Boffetta P, Chabrier A, Byrnes G, et al. Lung cancer susceptibility locus at 5p15.33. Nat Genet. 2008;40:1404-. CrossRef
  11. Haiman CA, Chen GK, Vachon CM, Canzian F, Dunning A, Millikan RC, et al. A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer. Nat Genet. 2011;43:1210-. CrossRef
  12. Petersen GM, Amundadottir L, Fuchs CS, Kraft P, Stolzenberg-Solomon RZ, Jacobs KB, et al. A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet. 2010;42:224-. CrossRef
  13. Rafnar T, Sulem P, Stacey SN, Geller F, Gudmundsson J, Sigurdsson A, et al. Sequence variants at the TERT-CLPTM1L locus associate with many cancer types. Nat Genet. 2009;41:221-. CrossRef
  14. Yamamoto K, Okamoto A, Isonishi S, Ochiai K, Ohtake Y. A novel gene, CRR9, which was up-regulated in CDDP-resistant ovarian tumor cell line, was associated with apoptosis. Biochem Biophys Res Commun. 2001;280:1148-4. CrossRef
  15. Ni Z, Tao K, Chen G, Chen Q, Tang J, Luo X, et al. CLPTM1L is overexpressed in lung cancer and associated with apoptosis. PLoS ONE. 2012;7:e52598. CrossRef
  16. James MA, Wen W, Wang Y, Byers LA, Heymach JV, Coombes KR, et al. Functional characterization of CLPTM1L as a lung cancer risk candidate gene in the 5p15.33 locus. PLoS ONE. 2012;7:e36116. CrossRef
  17. Pande M, Spitz MR, Wu X, Gorlov IP, Chen WV, Amos CI. Novel genetic variants in the chromosome 5p15.33 region associate wit
• 作者单位：Yiqian Liang (1)
  Asmitananda Thakur (1)
  Lei Gao (1)
  Ting Wang (1)
  Shuo Zhang (1)
  Hui Ren (1)
  Junhui Meng (1)
  Tingting Geng (2)
  Tianbo Jin (2)
  Mingwei Chen (1)
  
  1. Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of School of Medicine of Xi’an Jiaotong University, 277 Yanta West Street, Xi’an, 710061, People’s Republic of China
  2. National Engineering Research Center for Miniaturized Detection Systems, College of Life Sciences, Northwest University, Xi’an, 710069, Shaanxi Province, People’s Republic of China
  
• 刊物主题：Cancer Research;
• 出版者：Springer Netherlands
• ISSN：1423-0380

文摘

The implication of genetic factors in predisposition to cancer is a recognized fact. The Cleft lip and palate transmembrane 1-like (CLPTM1L) gene resides in a locus in the chromosome 5p15.33 region that is associated with lung cancer susceptibility and has a role in carcinogenesis. We conducted a case-control study in a Chinese population of 309 pathologically confirmed lung cancer patients and 310 controls to investigate the effect of variant genotypes within the CLPTM1L locus on susceptibility to lung cancer and sensitivity to cisplatin-based chemotherapy. We genotyped nine single nucleotide polymorphisms (SNPs) within the CLPTM1L locus and examined their correlation with lung cancer risk and treatment response using χ 2 and unconditional logistic regression analysis. We identified rs451360 as a novel SNP associated with lung cancer risk in the Chinese Han population. The “T-allele of rs451360 was associated with decreased risk of lung cancer (p--.007, odd ratio (OR)--.59, 95?% confidence interval (CI): 0.40-.87). Significant multiplicative interactions were observed between gender and polymorphisms of rs402710, the “T/T-genotype of which was associated with decreased lung cancer risk in male patients (p--.016, OR--.35, 95?% CI: 0.17-.73). CLPTM1L polymorphisms did not affect the tumor sensitivity to cisplatin combination chemotherapy in our study patients. The results of the present study suggest a potential association between CLPTM1L variants and lung cancer risk in the Chinese Han populations.