Association between CLPTM1L–TERT rs401681 polymorphism and risk of pancreatic cancer: a meta-analysis

详细信息    查看全文

• 作者：Cheng-Li Liu ; Xiao-Xia Zang ; Cheng Wang ; Ya-Lin Kong…
• 关键词：Pancreatic cancer ; Telomerase reverse transcriptase (TERT) ; Cleft lip and palate trans ; membrane 1 ; like (CLPTM1L) gene ; Polymorphism
• 刊名：Clinical and Experimental Medicine
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：15
• 期：4
• 页码：477-482
• 全文大小：684 KB
• 参考文献：1.Maisonneuve P, Lowenfels AB. Epidemiology of pancreatic cancer: an update. Dig Dis. 2010;28:645-6.CrossRef PubMed
  2.Bednar F, Simeone DM. Pancreatic cancer stem cell biology and its therapeutic implications. J Gastroenterol. 2011;46:1345-2.CrossRef PubMed
  3.Hansel DE, Kern SE, Hruban RH. Molecular pathogenesis of pancreatic cancer. Annu Rev Genomics Hum Genet. 2003;4:237-6.CrossRef PubMed
  4.Vaccaro V, Gelibter A, Bria E, et al. Molecular and genetic bases of pancreatic cancer. Curr Drug Targets. 2012;13:731-3.CrossRef PubMed
  5.Nakao M, Hosono S, Ito H, et al. Selected polymorphisms of base excision repair genes and pancreatic cancer risk in Japanese. J Epidemiol. 2012;22:477-3.CrossRef PubMed
  6.Krejs GJ. Pancreatic cancer: epidemiology and risk factors. Dig Dis. 2010;28:355-.CrossRef PubMed
  7.Luo J, Iwasaki M, Inoue M, et al. Body mass index, physical activity and the risk of pancreatic cancer in relation to smoking status and history of diabetes: a large-scale population-based cohort study in Japan—the JPHC study. Cancer Causes Control. 2007;18:603-2.CrossRef PubMed
  8.Wang Y, Broderick P, Webb E, et al. Common 5p15.33 and 6p21.33 variants influence lung cancer risk. Nat Genet. 2008;40:1407-.PubMedCentral CrossRef PubMed
  9.Rafnar T, Sulem P, Stacey SN, et al. Sequence variants at the TERT-CLPTM1L locus associate with many cancer types. Nat Genet. 2009;41:221-.PubMedCentral CrossRef PubMed
  10.Stacey SN, Sulem P, Masson G, et al. New common variants affecting susceptibility to basal cell carcinoma. Nat Genet. 2009;41:909-4.PubMedCentral CrossRef PubMed
  11.Petersen GM, Amundadottir L, Fuchs CS, et al. A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet. 2010;42:224-.PubMedCentral CrossRef PubMed
  12.Shay JW, Wright WE. Role of telomeres and telomerase in cancer. Semin Cancer Biol. 2011;21:349-3.PubMedCentral CrossRef PubMed
  13.Gomez DE, Armando RG, Farina HG, et al. Telomere structure and telomerase in health and disease (review). Int J Oncol. 2012;41:1561-.PubMedCentral PubMed
  14.Yamamoto K, Okamoto A, Isonishi S, Ochiai K, Ohtake Y. A novel gene, CRR9, which was up-regulated in CDDP-resistant ovarian tumor cell line, was associated with apoptosis. Biochem Biophys Res Commun. 2001;280:1148-4.CrossRef PubMed
  15.Wu C, Miao X, Huang L, et al. Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations. Nat Genet. 2012;44:62-.CrossRef
  16.DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177-8.CrossRef PubMed
  17.Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557-0.PubMedCentral CrossRef PubMed
  18.Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629-4.PubMedCentral CrossRef PubMed
  19.Harsha HC, Kandasamy K, Ranganathan P, et al. A compendium of potential biomarkers of pancreatic cancer. PLoS Med. 2009;6:e1000046.PubMedCentral CrossRef PubMed
  20.Bauer AS, Keller A, Costello E, et al. Diagnosis of pancreatic ductal adenocarcinoma and chronic pancreatitis by measurement of microRNA abundance in blood and tissue. PLoS One. 2012;7:e34151.PubMedCentral CrossRef PubMed
  21.Yachida S, Iacobuzio-Donahue CA. Evolution and dynamics of pancreatic cancer progression. Oncogene. 2013;32:5253-0.CrossRef PubMed
  22.Iacobuzio-Donahue CA, Velculescu VE, Wolfgang CL, Hruban RH. Genetic basis of pancreas cancer development and progression: insights from whole-exome and whole-genome sequencing. Clin Cancer Res. 2012;18:4257-5.PubMedCentral CrossRef PubMed
  23.McGrath M, Wong JY, Michaud D, Hunter DJ, De Vivo I. Telomere length, cigarette smoking, and bladder cancer risk in men and women. Cancer Epidemiol Biomarkers Prev. 2007;16:815-.CrossRef PubMed
  24.Jang JS, Choi YY, Lee WK, et al. Telomere length and the risk of lung cancer. Cancer Sci. 2008;99:1385-.CrossRef PubMed
  25.Risques RA, Vaughan TL, Li X, et al. Leukocyte telomere length predicts cancer risk in Barrett’s esophagus. Cancer Epidemiol Biomarkers Prev. 2007;16(26):49-5.
  26.Hou L, Savage SA, Blaser MJ, et al. Telomere length in peripheral leukocyte DNA and gastric cancer risk. Cancer Epidemiol Biomarkers Prev. 2009;18:3103-.PubMedCentral CrossRef PubMed
  27.Willeit P, Willeit J, Mayr A, et al. Telomere length and risk of incident cancer and cancer mortality. JAMA. 2010;304:69-5.CrossRef PubMed
  28.Willeit P, Willeit J, Kloss-Brandstatter A, Kronenberg F, Kiechl S. Fifteen-year follow-up of association between telomere length and incident cancer and cancer mortality. JAMA. 2011;306:42-.CrossRef PubMed
  29.Kobitsu K, Tsutsumi M, Tsujiuchi T, et al. Shortened telomere length and increased telomerase activity in hamster pancreatic duct adenocarci
• 作者单位：Cheng-Li Liu (1)
  Xiao-Xia Zang (2)
  Cheng Wang (1)
  Ya-Lin Kong (1)
  Hui Zhang (1)
  Hong-Yi Zhang (1)
  
  1. Department of Hepatobiliary Surgery, Air Force General Hospital of PLA, No. 30, Fucheng Road, Haidian District, Beijing, 100142, People’s Republic of China
  2. Department of Stomatology, Air Force General Hospital of PLA, Beijing, 100142, People’s Republic of China
  
• 刊物主题：Internal Medicine; Hematology; Oncology;
• 出版者：Springer Milan
• ISSN：1591-9528

文摘

Telomere biology plays a critical and complex role in the initiation and progression of cancer. Several recent studies have provided evidence that rs401681 polymorphisms in intronic region of cleft lip and palate trans-membrane 1-like (CLPTM1L) gene sequence are associated with pancreatic cancer (PC) development, but a comprehensive synopsis is not available. We performed a meta-analysis of 6 case–control studies that included 8,253 pancreatic cancer cases and 37,646 case-free controls. We assessed the strength of the association, using odds ratios (ORs) with 95 % confidence intervals (CIs). Overall, this meta-analysis showed that rs401681 allele T was associated with a significantly increased PC risk (OR = 1.17, 95 % CI = 1.12-.22, P _{heterpgeneity} = 0.596 and I 2 = 0). Similarly, in the subgroup analysis by ethnicity, a significantly increased risk was found among Asians (OR = 1.15, 95 % CI = 1.07-.24, P _{heterpgeneity} = 0.297 and I 2 = 8.0 %) and among Caucasian (OR = 1.13, 95 % CI = 1.02-.26, P _{heterpgeneity} = 0.385 and I 2 = 0). No publication bias was found in the present study. This meta-analysis suggests that T allele of CLPTM1L–telomerase reverse transcriptase rs401681 polymorphism is associated with an increased PC risk, especially among Chinese. Further large and well-designed studies are needed to confirm this association. Keywords Pancreatic cancer Telomerase reverse transcriptase (TERT) Cleft lip and palate trans-membrane 1-like (CLPTM1L) gene Polymorphism