Preparation of biodegradable PCL particles via double emulsion evaporation method using ultrasound technique

详细信息    查看全文

• 作者：Muhammad Iqbal (1)
  Jean-Pierre Valour (1)
  Hatem Fessi (1)
  Abdelhamid Elaissari (1)
  
  1. University of Lyon ; University Lyon-1 ; CNRS ; UMR 5007 ; LAGEP-CPE ; 43 Bd. 11 Novembre 1918 ; F-69622 ; Villeurbanne ; France
  
• 关键词：Double emulsion process ; Nanoparticles ; Colloidal properties ; Parameters ; Size ; Ultrasound
• 刊名：Colloid & Polymer Science
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：293
• 期：3
• 页码：861-873
• 全文大小：1,989 KB
• 参考文献：1. Rosset, V, Ahmed, N, Zaanoun, I, Stella, B, Fessi, H, Elaissari, A (2012) Elaboration of argan oil nanocapsules containing naproxen for cosmetic and transdermal local application. J Colloid Sci Biotechnol 1: pp. 218-224 CrossRef
  2. Campos, EVR, Melo, NFS, Paula, E, Rosa, AH, Fraceto, LF (2013) Screening of conditions for the preparation of poly( 鈭抍aprolactone) nanocapsules containing the local anesthetic articaine. J Colloid Sci Biotechnol 2: pp. 106-111 CrossRef
  3. Doustgani, A, Farahani, EV, Imani, M, Doulabi, AH (2012) Dexamethasone sodium phosphate release from chitosan nanoparticles prepared by ionic gelation method. J Colloid Sci Biotechnol 1: pp. 42-50 CrossRef
  4. Palomino, D, Yamunake, C, Coustumer, PL, Stoll, S (2013) Stability of TiO2 nanoparticles in presence of fulvic acids. Importance of pH. J Colloid Sci Biotechnol 2: pp. 62-69 CrossRef
  5. Medina, C, Santos-Martinez, MJ, Radomski, A, Corrigan, OI, Radomski, MW (2007) Nanoparticles: pharmacological and toxicological significance. Br J Pharmacol 150: pp. 552-558 CrossRef
  6. Florence, AT, Whitehill, D (1982) The formulation and stability of multiple emulsions. Int J Pharm 11: pp. 277-308 CrossRef
  7. Giri, TK, Choudhary, C, Ajazuddin, , Alexander, A, Badwaik, H, Tripathi, DK (2013) Prospects of pharmaceuticals and biopharmaceuticals loaded microparticles prepared by double emulsion technique for controlled delivery. Saudi Pharm J 21: pp. 125-141 CrossRef
  8. Ayoub, M, Ahmed, N, Kalaji, N, Charcosset, C, Magdy, A, Fessi, H, Elaissari, A (2011) Study of the effect of formulation parameters/variables to control the nanoencapsulation of hydrophilic drug via double emulsion technique. J Biomed Nanotechnol 7: pp. 255-262 CrossRef
  9. Nedovic, V, Kalusevic, A, Manojlovic, V, Levic, S, Bugarski, B (2011) An overview of encapsulation technologies for food applications. Procedia Food Sci 1: pp. 1806-1815 CrossRef
  10. Khan, AU, Ahmad, NM, Mahmood, N (2012) Rheological studies on stabilised zirconia aqueous suspensions. J Colloid Sci Biotechnol 1: pp. 175-184 CrossRef
  11. Malacrida, CR, Ferreira, S, Nicoletti Telis, VR (2013) Stability at different temperatures of turmeric oleoresin encapsulated in maltodextrin/gelatin matrices by freeze-drying. J Colloid Sci Biotechnol 2: pp. 100-105 CrossRef
  12. Nakada, Y, Fattal, E, Foulquier, M, Couvreur, P (1996) Pharmacokinetics and biodistribution of oligonucleotide adsorbed onto poly(isobutylcyanoacrylate) nanoparticles after intravenous administration in mice. Pharm Res 13: pp. 38-43 CrossRef
  13. Seifriz, W (1924) Studies in Emulsions. III-V. J Phys Chem 29: pp. 738-749 CrossRef
  14. Garti, N (1997) Double emulsions 鈥?scope, limitations and new achievements. Colloids Surf Physicochem Eng Asp 123鈥?24: pp. 233-246 CrossRef
  15. Khan, AY, Talegaonkar, S, Iqbal, Z, Ahmed, FJ, Khar, RK (2006) Multiple emulsions: an overview. Curr Drug Deliv 3: pp. 429-443 CrossRef
  16. Walstra, P (1993) Principles of emulsion formation. Chem Eng Sci 48: pp. 333-349 CrossRef
  17. Iqbal, M, Akhtar, N (2013) Formulation and Stability of a Cosmetic Emulsion Containing Extract of Strawberry. J Colloid Sci Biotechnol 2: pp. 309-314 CrossRef
  18. Jafari, SM, Assadpoor, E, He, Y, Bhandari, B (2008) Re-coalescence of emulsion droplets during high-energy emulsification. Food Hydrocoll 22: pp. 1191-1202 CrossRef
  19. Wei, B, Wang, S, Song, H, Liu, H, Li, J, Liu, N (2009) A review of recent progress in preparation of hollow polymer microspheres. Pet Sci 6: pp. 306-312 CrossRef
  20. Capek, I (2004) Preparation of metal nanoparticles in water-in-oil (w/o) microemulsions. Adv Colloid Interf Sci 110: pp. 49-74 CrossRef
  21. Fu, G-D, Li, GL, Neoh, KG, Kang, ET (2011) Hollow polymeric nanostructures鈥擲ynthesis, morphology and function. Prog Polym Sci 36: pp. 127-167 CrossRef
  22. Zambaux, M, Bonneaux, F, Gref, R, Maincent, P, Dellacherie, E, Alonso, M, Labrude, P, Vigneron, C (1998) Influence of experimental parameters on the characteristics of poly(lactic acid) nanoparticles prepared by a double emulsion method. J Control Release 50: pp. 31-40 CrossRef
  23. Ibraheem, D, Iqbal, M, Agusti, G, Fessi, H, Elaissari, A (2014) Effects of process parameters on the colloidal properties of polycaprolactone microparticles prepared by double emulsion like process. Colloids Surf Physicochem Eng Asp 445: pp. 79-91 CrossRef
  24. Lamprecht, A, Ubrich, N, Hombreiro P茅rez, M, Lehr, C-M, Hoffman, M, Maincent, P (2000) Influences of process parameters on nanoparticle preparation performed by a double emulsion pressure homogenization technique. Int J Pharm 196: pp. 177-182 CrossRef
  25. Lowery, JL, Datta, N, Rutledge, GC (2010) Effect of fiber diameter, pore size and seeding method on growth of human dermal fibroblasts in electrospun poly(蓻-caprolactone) fibrous mats. Biomaterials 31: pp. 491-504 CrossRef
  26. Zengshuan Ma, AH (2008) Micelles of poly(ethylene oxide)-b-poly(epsilon-caprolactone) as vehicles for the solubilization, stabilization, and controlled delivery of curcumin. J Biomed Mater Res A 86: pp. 300-310
  27. Fong JW (1981) French Patent no, FRA11694
  28. Xia, C, Xiao, C (2012) Preparation and characterization of dual responsive sodium alginate-g-poly(vinyl alcohol) hydrogel. J Appl Polym Sci 123: pp. 2244-2249 CrossRef
  29. Behrend, O, Ax, K, Schubert, H (2000) Influence of continuous phase viscosity on emulsification by ultrasound. Ultrason Sonochem 7: pp. 77-85 CrossRef
  30. Abisma茂l, B, Canselier, JP, Wilhelm, AM, Delmas, H, Gourdon, C (1999) Emulsification by ultrasound: drop size distribution and stability. Ultrason Sonochem 6: pp. 75-83 CrossRef
  31. Tadros, T, Izquierdo, P, Esquena, J, Solans, C (2004) Formation and stability of nano-emulsions. Adv Colloid Interface Sci 108鈥?09: pp. 303-318 CrossRef
  32. Li, MK, Fogler, HS (1978) Acoustic emulsification. Part 2. Breakup of the large primary oil droplets in a water medium. J Fluid Mech 88: pp. 513-528 CrossRef
  33. Mason TJ (1996) Advances in Sonochemistry. Elsevier
  34. Vilkhu, K, Manasseh, R, Mawson, R, Ashokkumar, M Ultrasonic recovery and modification of food ingredients. In: Feng, H, Barbosa-Canovas, G, Weiss, J eds. (2011) Ultrasound technologies for food and bioprocessing. Springer, New York, pp. 345-368 CrossRef
  35. Cucheval, A, Chow, RCY (2008) A study on the emulsification of oil by power ultrasound. Ultrason Sonochem 15: pp. 916-920 CrossRef
  36. Jafari, SM, He, Y, Bhandari, B (2007) Production of sub-micron emulsions by ultrasound and microfluidization techniques. J Food Eng 82: pp. 478-488 CrossRef
  37. Mahdi Jafari, S, He, Y, Bhandari, B (2006) Nano-Emulsion Production by Sonication and Microfluidization鈥擜 Comparison. Int J Food Prop 9: pp. 475-485 CrossRef
  38. Pisani, E, Fattal, E, Paris, J, Ringard, C, Rosilio, V, Tsapis, N (2008) Surfactant dependent morphology of polymeric capsules of perfluorooctyl bromide: influence of polymer adsorption at the dichloromethane-water interface. J Colloid Interface Sci 326: pp. 66-71 CrossRef
  39. Alex, R, Bodmeier, R (1990) Encapsulation of water-soluble drugs by a modified solvent evaporation method. I. Effect of process and formulation variables on drug entrapment. J Microencapsul 7: pp. 347-355 CrossRef
  40. Gaikwad, SG, Pandit, AB (2008) Ultrasound emulsification: Effect of ultrasonic and physicochemical properties on dispersed phase volume and droplet size. Ultrason Sonochem 15: pp. 554-563 CrossRef
  41. Tal-Figiel, B (2007) The Formation of Stable W/O, O/W, W/O/W Cosmetic Emulsions in an Ultrasonic Field. Chem Eng Res Des 85: pp. 730-734 CrossRef
  42. Jalil, R, Nixon, JR (1990) Biodegradable poly(lactic acid) and poly(lactide-co-glycolide) microcapsules: problems associated with preparative techniques and release properties. J Microencapsul 7: pp. 297-325 CrossRef
  43. S谩nchez-Silva, L, Rodr铆guez, JF, S谩nchez, P (2011) Influence of different suspension stabilizers on the preparation of Rubitherm RT31 microcapsules. Colloids Surf Physicochem Eng Asp 390: pp. 62-66 CrossRef
  44. Mora-Huertas, CE, Fessi, H, Elaissari, A (2011) Influence of process and formulation parameters on the formation of submicron particles by solvent displacement and emulsification鈥揹iffusion methods: Critical comparison. Adv Colloid Interface Sci 163: pp. 90-122 CrossRef
  45. Fong JW (1990) Process for preparation of microspheres. US4933105 A
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Polymer Sciences
  Physical Chemistry
  Soft Matter and Complex Fluids
  Characterization and Evaluation Materials
  Food Science
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1435-1536

文摘

Polymeric nanoparticles have attracted growing attention because of their unique properties and extensive application. In this study, polycaprolactone (PCL) nanoparticles were prepared via double emulsion solvent evaporation-like process using power ultrasound, and the effects of various process parameters on particle size, zeta potential, and morphology were investigated and optimized. Nanoparticles (NPs) were prepared by two-step emulsification process. In the first step, the inner aqueous phase (W1) was homogenized with organic phase (PCL in dichloromethane) to obtain primary emulsion. In the second step, the primary emulsion was emulsified with outer aqueous phase (W2) containing polyvinyl alcohol (PVA) as stabilizer using power ultrasound, followed by evaporation of solvent which resulted in a particulate suspension at the end. Effects of various parameters like ultrasound exposure time and amplitude, outer aqueous phase volume, PVA concentration, and PCL content were investigated. It has been shown that, by increasing ultrasound exposure time, amplitude, and outer aqueous phase volume, the particle size decreases. Additionally, particle size was also related to amount of PCL and PVA concentration. Spherical NPs with smooth surfaces were observed by scanning electron microscopy (SEM).