PGC-1α regulates the cell cycle through ATP and ROS in CH1 cells
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- 作者：Xu-feng Fu ; Kun Yao ; Xing Du ; Yan Li…
- 关键词：Peroxisome proliferator ; activated receptor ; γ coactivator 1α (PGC ; 1α) ; Mitochondria ; Oxidative phosphorylation (OXPHOS) ; Cell cycle ; CyclinD1 ; CyclinB1 ; 过氧化物酶体增殖物受体γ 共激活因子1α(PGC ; 1α) ; 线粒体 氧化磷酸化 细胞周期 ; CyclinD1 ; CyclinB1 ; Q25
- 刊名：Journal of Zhejiang University SCIENCE B
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：17
- 期：2
- 页码：136-146
- 全文大小：1,634 KB
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Kun Yao (1)
Xing Du (1)
Yan Li (1)
Xiu-yu Yang (1)
Min Yu (1)
Mei-zhang Li (1)
Qing-hua Cui (1)
1. School of Life Sciences, Yunnan University, Kunming, 650091, China
2. School of Medicine, Yunnan University, Kunming, 650091, China - 刊物主题：Biomedicine general;
- 出版者：Springer Berlin Heidelberg
- ISSN：1862-1783
文摘
Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) is a transcriptional co-activator involved in mitochondrial biogenesis, respiratory capacity, and oxidative phosphorylation (OXPHOS). PGC-1α plays an important role in cellular metabolism and is associated with tumorigenesis, suggesting an involvement in cell cycle progression. However, the underlying mechanisms mediating its involvement in these processes remain unclear. To elucidate the signaling pathways involved in PGC-1α function, we established a cell line, CH1 PGC-1α, which stably overexpresses PGC-1α. Using this cell line, we found that over-expression of PGC-1α stimulated extra adenosine triphosphate (ATP) and reduced reactive oxygen species (ROS) production. These effects were accompanied by up-regulation of the cell cycle checkpoint regulators CyclinD1 and CyclinB1. We hypothesized that ATP and ROS function as cellular signals to regulate cyclins and control cell cycle progression. Indeed, we found that reduction of ATP levels down-regulated CyclinD1 but not CyclinB1, whereas elevation of ROS levels down-regulated CyclinB1 but not CyclinD1. Furthermore, both low ATP levels and elevated ROS levels inhibited cell growth, but PGC-1α was maintained at a constant level. Together, these results demonstrate that PGC-1α regulates cell cycle progression through modulation of CyclinD1 and CyclinB1 by ATP and ROS. These findings suggest that PGC-1α potentially coordinates energy metabolism together with the cell cycle. Keywords Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) Mitochondria Oxidative phosphorylation (OXPHOS) Cell cycle CyclinD1 CyclinB1