Polymorphisms of the Peroxisome Proliferator-Activated Receptor-γ (rs1801282) and its coactivator-1 (rs8192673) are associated with obesity indexes in subjects with type 2 diabetes mellitus
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- 作者：Peter Kruzliak ; Andreana P Haley…
- 关键词：Peroxisome Proliferator ; Activated Receptor ; γ ; Peroxisome Proliferator ; Activated Receptor ; γ Coactivator ; 1 ; Gene polymorphism ; Association study ; Type 2 diabetes mellitus ; Obesity indexes
- 刊名：Cardiovascular Diabetology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：14
- 期：1
- 全文大小：630 KB
- 刊物主题：Diabetes; Angiology; Cardiology;
- 出版者：BioMed Central
- ISSN：1475-2840
文摘
ᅟ The aim of this study was to clarify whether common single nucleotide polymorphisms (SNPs) of the Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ) gene (rs1801282) and the Peroxisome Proliferator-Activated Receptor-γ Coactivator-1 (PGC-1α) gene (rs8192673) are associated with obesity indexes (BMI, waist circumference) in subjects with type 2 diabetes mellitus (T2DM) in Caucasian population. The second aim was to find an association of both polymorphisms with T2DM.