A cognitive electrophysiological signature differentiates amnestic mild cognitive impairment from normal aging
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- 作者：Juan Li ; Lucas S. Broster ; Gregory A. Jicha…
- 关键词：Amnestic mild cognitive impairment ; Alzheimer’s disease ; Event ; related potentials ; Working memory ; Early detection
- 刊名：Alzheimer's Research & Therapy
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：9
- 期：1
- 全文大小：1755KB
- 刊物主题：Neurosciences; Neurology; Geriatrics/Gerontology; Geriatric Psychiatry;
- 出版者：BioMed Central
- ISSN：1758-9193
- 卷排序：9
文摘
BackgroundNoninvasive and effective biomarkers for early detection of amnestic mild cognitive impairment (aMCI) before measurable changes in behavioral performance remain scarce. Cognitive event-related potentials (ERPs) measure synchronized synaptic neural activity associated with a cognitive event. Loss of synapses is a hallmark of the neuropathology of early Alzheimer’s disease (AD). In the present study, we tested the hypothesis that ERP responses during working memory retrieval discriminate aMCI from cognitively normal controls (NC) matched in age and education.