Portal myofibroblasts connect angiogenesis and fibrosis in liver

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• 作者：Sara Lemoinne ; Dominique Thabut ; Chantal Housset
• 关键词：COL15A1 ; Mesenchymal progenitor cells ; Hepatic stellate cells ; Liver fibrosis ; Angiogenesis
• 刊名：Cell and Tissue Research
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：365
• 期：3
• 页码：583-589
• 全文大小：1,608 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Human Genetics
  Proteomics
  Molecular Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0878
• 卷排序：365

文摘

Liver fibrogenesis is a dynamic process including quantitative and qualitative changes of the extracellular matrix, of which the most prominent is the deposition of type I collagen. These changes progressively disrupt normal liver architecture and result in cirrhosis formation. In the fibrotic liver, as in all other fibrotic tissues, the extracellular matrix is produced by cells usually characterized by the de novo expression of alpha-smooth muscle actin and known as myofibroblasts. Portal myofibroblasts (PMFs) appear to be critical in pathological angiogenesis, which constantly occurs in advanced liver fibrosis. Whereas the association between angiogenesis and fibrosis during the progression of liver diseases remains to be elucidated, we suggest that collagen-type-XV-alpha1-producing PMFs could provide an important link both by stabilizing newly formed vessels and by forming a scaffold for the deposition of interstitial collagen.