The nephrologist of tomorrow: towards a kidney-omic future

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• 作者：Mina H. Hanna ; Alessandra Dalla Gassa ; Gert Mayer ; Gianluigi Zaza…
• 关键词：Omics ; Systems biology ; SysKid ; Biomarkers ; Pediatric nephrology
• 刊名：Pediatric Nephrology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：32
• 期：3
• 页码：393-404
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Pediatrics; Nephrology; Urology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-198X
• 卷排序：32

文摘

Omics refers to the collective technologies used to explore the roles and relationships of the various types of molecules that make up the phenotype of an organism. Systems biology is a scientific discipline that endeavours to quantify all of the molecular elements of a biological system. Therefore, it reflects the knowledge acquired by omics in a meaningful manner by providing insights into functional pathways and regulatory networks underlying different diseases. The recent advances in biotechnological platforms and statistical tools to analyse such complex data have enabled scientists to connect the experimentally observed correlations to the underlying biochemical and pathological processes. We discuss in this review the current knowledge of different omics technologies in kidney diseases, specifically in the field of pediatric nephrology, including biomarker discovery, defining as yet unrecognized biologic therapeutic targets and linking omics to relevant standard indices and clinical outcomes. We also provide here a unique perspective on the field, taking advantage of the experience gained by the large-scale European research initiative called “Systems Biology towards Novel Chronic Kidney Disease Diagnosis and Treatment” (SysKid). Based on the integrative framework of Systems biology, SysKid demonstrated how omics are powerful yet complex tools to unravel the consequences of diabetes and hypertension on kidney function.