Follicular adenoma associated with spindle cell proliferation, papillary adenoma and colloid goitre in a dromedary camel

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• 作者：Mohamed H. Tageldin ; Hassan Abu Damir ; Elhag A. Omer…
• 关键词：Dromedary camel ; Thyroid follicular and papillary adenoma ; Spindle cell proliferation ; Subclinical colloid goitre
• 刊名：Comparative Clinical Pathology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：25
• 期：1
• 页码：241-245
• 全文大小：1,612 KB
• 参考文献：Agaimy A, Hahn T, Schroeder J, Afaf E (2012) Follicular thyroid adenoma dominated by spindle cells: report of two unusual cases and literature review. Int J Clin Exp Pathol 5:143–151PubMed
  Aker FV, Bas Y, Ozkara S, Peker O (2004) Spindle cell metaplasia in follicular adenoma of the thyroid gland: case report and review of the literature. Endocr J 51:457–461PubMed CrossRef
  Baloch ZW, Wu H, LiVolsi VA (1999) Post-fine needle aspiration spindle cell nodules of the thyroid (PSCNT). Am J Clin Pathol 111:70–74PubMed
  Cameselle-Teijeiro J, Varela-Duran J, Fonseca E, Villanueva JP, Sobrinho-Simones M (1994) Solitary fibrous tumor of the thyroid. Am J Clin Pathol 101:535–538PubMed
  Dako (2012). Atlas of stains, 4th edition pp: 20 & 60. www.​dako.​com/​00230_​atlas_​stains.​pdf
  Das DK (2009) Psammoma body: a product of dystrophic calcification or of a biologically active process that aims at limiting the growth and spread of tumor? Diagn Cytopathol 37:534–541PubMed CrossRef
  El Demellawy, D. Nasr A., Alowami S. (2008). Application of CD56, P63 and CK 19 immunohistochemistry in the diagnosis of papillary carcinoma of the thyroid. Diagnostic pathology, 3, 5 doi: 10.​1186/​1746-1596-3-5 . http://​www.​diagnosticpathol​ogy.​org/​content/​3/​1/​5
  Faye B, Seboussi R (2009) Selenium in camel. A review. Nutrients 1:30–49PubMed PubMedCentral CrossRef
  Garner MM, Shwetz C, Ramer JC, Rasmussen JM, Petrini K, Cowan DF, Raymond JT, Bossart GD, Levine GA (2002) Congenital diffuse hyperplastic goiter associated with perinatal mortality in 11 captive-born bottlenose dolphins (Tursiops truncatus). J Zoo Wildl Med 33:350–355PubMed CrossRef
  Hirokawa M, Haba R, Kushida Y, Bando K, Kuma S, Kihara M, Miyauchi A (2010) Benign nodular goiter with spindle cell component. Pathol Int 60:586–590PubMed CrossRef
  Jones TC, Hunt RD, King NW (1997) Veterinary pathology, 6th edn. Williams & Wilkins, Baltimore, p p1236
  Kobayashi R, Yamada N, Kitamori T, Kitamori F, Sato K, Doi T, Wako Y, Sato J, Tsuchitani M (2014) Follicular thyroid carcinoma characterized by abundant stromal components with chondroid and osseous metaplasia in a dog. J Vet Med Sci 76:1161–1164PubMed PubMedCentral CrossRef
  Magro G, Torrisi A, Torrisi A (2005a) Atypical/bizarre spindle-cell epithelial metaplasia in nodular goiter: a potential diagnostic pitfall. Virchows Archieve 446:91–92CrossRef
  Magro G, Benkova K, Michal M (2005b) Meningioma-like tumor of the thyroid. A previously undescribed variant of follicular adenoma. Virchows Archieve 446:677–679CrossRef
  Nel CJ, van Heerden JA, Goellner JR, Gharib H, McConahey WM, Taylor WF, Grant CS (1985) Anaplastic carcinoma of the thyroid: a clinicopathological study of 82 cases. Mayo Clin Proc 60:51–58PubMed CrossRef
  Papotti M, Sambataro D, Pecchioni C, Bussolati G (1996) The pathology of medullary carcinoma of the thyroid: review of the literature and personal experience on 62 cases. Endocr Pathol 7:1–20PubMed CrossRef
  Rosai J, Kuhn E, Carcangiu ML (2006) Pitfalls in thyroid tumour pathology. Histopathology 49:107–120PubMed CrossRef
  Saeb M, Baghshani H, Nazifi S, Saeb S (2010) Physiological response of dromedary camels to road transportation in relation to circulating levels of cortisol, thyroid hormones and some serum biochemical parameters. Trop Anim Health Prod 42:55–63PubMed CrossRef
  Sato K, Shimode Y, Hirokawa M, Ueda Y, Katsuda S (2008) Thyroid adenomatous nodule with bizarre nuclei: a case report and mutation analysis of the p53 gene. Pathol Res Pract 204:191–195PubMed CrossRef
  Scognamiglio T, Hyjek E, Kao J, Chen Y (2006) Diagnostic usefulness of HBME1, galectin-3, CK 19, and CITED and evaluation of their expression in encapsulated lesions with questionable features of papillary thyroid carcinoma. Am J Clin Pathol 126:700–708PubMed CrossRef
  Shikama Y, Mizukami H, Sakai T, Yagihashi N, Okamoto K, Yagihashi S (2006) Spindle cell metaplasia arising in thyroid adenoma: characterization of its pathology and differential diagnosis. J Endocrinol Inv 29:168–171CrossRef
  Than TH, Swethadri GK, Wong J, Ahmad T, Jamil D, Maganlal RK, Hamdi MM, Abdullah MS (2008) Expression of galectin 3 and galectin 7 in thyroid malignancy as potential diagnostic indicators. Singap Med J 99:333–338
  Vergilio J, Baloch ZW, LiVolsi VA (2002) Spindle cell metaplasia of the thyroid arising in association with papillary carcinoma and follicular adenoma. Am J Clin Pathol 117:199–204PubMed CrossRef
  Williams ED (2000) Two proposals regarding the terminology of thyroid tumours. Int J Pathol 8:181–183CrossRef
  Woenckhaus C, Cameselle-Teijeiro J, Ruiz-Ponte C, Abdulkader I, Reyes-Santias R, Sobrinho-Simoes M (2004) Spindle cell variant of papillary thyroid carcinoma. Histopathology 45:424–427PubMed CrossRef
  Yadegari M, Aziz S, Khamesipour F (2014) Evaluation of prevalence of the types of thyroid disorders using ultrasound and pathology of one humped camel (Camelus dromedarius). Kafkas Universitesi Veteriner Fakultesi Dergisi 20:605–611
  
• 作者单位：Mohamed H. Tageldin (1)
  Hassan Abu Damir (2)
  Elhag A. Omer (3)
  Mahmoud A. Ali (4)
  Adam M. Adam (5)
  
  1. Department of Animal and Veterinary Sciences, College of Agricultural and Marine Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman
  2. PO Box 85689, Al Ain, United Arab Emirates
  3. Veterinary Laboratory, The Department of Agriculture, Al Ain, United Arab Emirates
  4. College of Medicine, UAE University, Al Ain, United Arab Emirates
  5. Laboratories and Animal Research Centre, Directorate general of Veterinary Services, Royal Court Affairs, Muscat, Sultanate of Oman
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Pathology
  Hematology
  Oncology
  
• 出版者：Springer London
• ISSN：1618-565X

文摘

In humans, spindle cell lesions associated with thyroid adenoma or carcinoma are rare. A cross section of the thyroid of a dromedary camel showed follicular cysts, and microscopically, both thyroid lobes showed colloid goitre. The left lobe showed spindle cell proliferation associated with follicular adenoma without evidence of capsular or vascular invasion. The spindle cell lesion had cells featuring ground glass or pseudoinclusion nuclei and showed extensive haemorrhage, hyalinization and thrombosis. The right thyroid lobe showed papillary adenoma. Immunohistochemistry showed negative expression for malignancy. Serum Se, free tri-iodothyronine (fT3) and free thyroxine (fT4) values were low and CK activity was high. The histological features were unusual and merit reporting. Keywords Dromedary camel Thyroid follicular and papillary adenoma Spindle cell proliferation Subclinical colloid goitre