Diverse forms of HIV-1 among Burmese long-distance truck drivers imply their contribution to HIV-1 cross-border transmission

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• 作者：Yan-Heng Zhou (13) (16) (17)
  Yue-Bo Liang (14)
  Wei Pang (13)
  Wei-Hong Qin (14)
  Zhi-Hong Yao (13) (16)
  Xin Chen (13) (16)
  Chiyu Zhang (15)
  Yong-Tang Zheng (13)
  
  13. Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province ; Kunming Institute of Zoology ; Chinese Academy of Sciences ; Kunming ; Yunnan ; China
  16. University of the Chinese Academy of Sciences ; Beijing ; 100049 ; China
  17. Shaanxi Engineering & Technological Research Center for Conversation & Utilization of Regional Biological Resources ; College of Life Sciences ; Yan鈥檃n University ; Yan鈥檃n ; Shaanxi ; 716000 ; China
  14. Yunnan International Travel Healthcare Center ; Kunming ; Yunnan ; 650200 ; China
  15. Pathogen Diagnostic Center ; Institut Pasteur of Shanghai ; Chinese Academy of Sciences ; Shanghai ; 200025 ; China
  
• 关键词：LDTDs ; HIV ; 1 subtype ; Recombination ; Transmission ; China ; Myanmar border
• 刊名：BMC Infectious Diseases
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：14
• 期：1
• 全文大小：1,187 KB
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  26. The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-2334/14/463/prepub
  
• 刊物主题：Infectious Diseases; Parasitology; Medical Microbiology; Tropical Medicine; Internal Medicine;
• 出版者：BioMed Central
• ISSN：1471-2334

文摘

Background The China-Myanmar border is a particularly interesting region that has very high prevalence of and considerable diversity of HIV-1 recombinants. Due to the transient nature of their work, long-distance truck drivers (LDTDs) have a comparatively high potential to become infected with HIV-1 and further spread virus to other individuals in the area they travel within. In this study, we hypothesized that Burmese LDTDs crossing the China-Myanmar border frequently may potentially be involved in the cross-border transmission of HIV, and contribute to the extremely high prevalence of HIV-1 inter-subtype recombinants in this border region. Methods A molecular epidemiology study was conducted among 105 Burmese LDTDs between 2008 and 2010. HIV-1 genetic fragments including p17, pol, vif-vpr, vpr-env, and C2V3 were amplified and sequenced. The subtype characterization and HIV-1 transmission were determined by both phylogenetic and phylogeographic analyses. Results Diverse forms of HIV-1, including subtypes CRF01_AE (41.9%), C (8.6%), B (4.8%), CRF02_AG (1.0%), and inter-subtype recombinants (33.3%), as well as dual infection (10.5%), were detected among the tested LDTDs. Phylogeographic analyses based on pure subtype revealed that 77.8% Burmese LDTDs acquired HIV-1 infection in Yunnan, and the others in Myanmar. Both the C-related and CRF01_AE-related recombinants from these LDTDs appeared to have close genetic relationship with those from IDUs in Myanmar and Dehong. Conclusions Burmese LDTDs may contribute to HIV-1 transmission along the China-Myanmar border. The results may provide some new perspective for understanding the on-going generation and prevalence of HIV-1 recombinants in the border region.