Study on single crystal structure of the antimony(III) bromide complex with 3-methyl-2-mercaptobenzothiazole and biological activity of some antimony(III) bromide complexes with thioamides
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- 作者：I. I. Ozturk (1) (6)
A. K. Metsios (1) (4)
S. Filimonova-Orlova (1) (5)
N. Kourkoumelis (2)
S. K. Hadjikakou (1)
M. Manos (3)
A. J. Tasiopoulos (3)
S. Karkabounas (4)
E. R. Milaeva (5)
N. Hadjiliadis (1) - 关键词：Bioinorganic medicinal chemistry ; Antimony(III) bromide complexes ; 3 ; Methyl ; 2 ; mercaptobenzothiazole ; Lipoxygenase ; Antitumor activity
- 刊名：Medicinal Chemistry Research
- 出版年：2012
- 出版时间：November 2012
- 年：2012
- 卷：21
- 期：11
- 页码：3523-3531
- 全文大小：587KB
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28. Xanthopoulou MN, Hadjikakou SK, Hadjiliadis N, Milaeva ER, Gracheva JA, Tyurin VY, Kourkoumelis N, Christoforidis KC, Metsios AK, Karkabounas S, Charalabopoulos K (2008) Biological studies of new organotin(IV) complexes of thioamide ligands. Eur J Med Chem 43:327-35 CrossRef
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A. K. Metsios (1) (4)
S. Filimonova-Orlova (1) (5)
N. Kourkoumelis (2)
S. K. Hadjikakou (1)
M. Manos (3)
A. J. Tasiopoulos (3)
S. Karkabounas (4)
E. R. Milaeva (5)
N. Hadjiliadis (1)
1. Section of Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, 45110, Ioannina, Greece
6. Section of Inorganic Chemistry Department of Chemistry, Nam?k Kemal University, Tekirdag, Turkey
4. Department of Experimental Physiology, Medical School, University of Ioannina, Ioannina, Greece
5. Department of Chemistry, M. V. Lomonosov Moscow State University, 1 Leninskie Gory, 119992, Moscow, Russian Federation
2. Medical Physics Laboratory, Medical School, University of Ioannina, Ioannina, Greece
3. Department of Chemistry, University of Cyprus, 1678, Nicosia, Cyprus
文摘
Crystals of the [SbBr3(MMBZT)2] (1) complex (MMBZT?=?N-methyl-2-mercaptobenzothiazole) were grown from acetonitrile/methanol of the filtrate derived from the reaction between 3-methyl-2-mercaptobenzothiazole (MMBZT) in methanol, with antimony(III) bromide in acetonitrile. The crystal structure of 1 (C16H14Br3N2S4Sb) was determined by X-ray diffraction at 100(2)?K, in space group P-1, with a?=?10.738(2)??, b?=?11.387(3)??, c?=?11.439(3)??, α?=?62.764°, β?=?63.36(2)°, γ?=?85.074(2)°, and Z?=?2. The geometry around the metal center of complex 1 is square pyramidal, with two sulfur atoms from thione ligands and three bromide anions around Sb(III). Complex is monomer. The equatorial plane is formed by two sulfur and two bromide atoms in complex, in a cis-S, cis-Br arrangement. The in vitro cytotoxicity against leiomyosarcoma cells (LMS) of antimony(III) bromide complexes with thioamide ligands with formulae: [SbBr3(MMBZT)2] (1), [SbBr3(TU)2] (2), [SbBr3(MMI)2] (3), {[SbBr2(MBZIM)4]+·[Br]?/sup>·H2O} (4), {[SbBr2(μ 2-Br)(MMBZIM)2]2} (5), {[SbBr2(μ 2-Br)(EtMBZIM)2]2·MeOH} (6), {[SbBr3(μ 2-S-tHPMT)(tHPMT)] n } (7), {[SbBr2(μ 2-Br)(PYT)2) n } (8), {[SbBr2(μ 2-Br)(MTZD)2] n } (9), and {[SbBr5]2?/sup>[(PMTH2 +)2]} (10) (where TU?=?thiourea, MMI?=?methylimidazole, MBZIM?=?2-mercaptobenzimidazole, MMBZIM?=?2-mercapto-5-methyl-benzimidazole, EtMBZIM?=?5-ethoxy-2-mercaptobenzimidazole, tHPMT?=?2-mercapto-3,4,5,6-tetrahydro-pyrimidine, PYT?=?2-mercaptopyridine, MTZD?=?2-mercapto-thiazolidine, and PMTH?=?2-mercaptopyrimidine) were evaluated. Complex 8 shows the strongest activity against LMS cells with IC50 value 1.7?±?0.1?μΜ. The results are compared with their activity against human cervix carcinoma cell lines. Complexes 1, 6-strong class="a-plus-plus">9 were also tested for their inhibitory activity upon the catalytic peroxidation of linoleic acid to hydroperoxylinoleic acid by the enzyme lipoxygenase. Computational studies using multivariate linear regression and considering biological results (50% inhibitory concentration, IC50) as dependent variables derived a theoretical equation for IC50 values of the complexes studied. The calculated IC50 values are compared adequately with the experimental inhibitory activity of the complexes measured.