Identification of cytoprotective constituents of the flower buds of Tussilago farfara against glucose oxidase-induced oxidative stress in mouse fibroblast NIH3T3 cells and human keratinocyte HaCaT cells

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• 作者：Unwoo Kang ; Jiyoung Park ; Ah-Reum Han ; Mi Hee Woo…
• 关键词：Tussilago farfara ; Compositae ; Phenolic compound ; Cytoprotection ; Oxidative stress
• 刊名：Archives of Pharmacal Research
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：39
• 期：4
• 页码：474-480
• 全文大小：435 KB
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• 作者单位：Unwoo Kang (1)
  Jiyoung Park (1)
  Ah-Reum Han (1)
  Mi Hee Woo (2)
  Je-Hyun Lee (3)
  Sang Kook Lee (4)
  Tong-Shin Chang (1)
  Hyun Ae Woo (1)
  Eun Kyoung Seo (1)
  
  1. College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Korea
  2. College of Pharmacy, Catholic University of Daegu, Gyeongsan, 38430, Korea
  3. Department of Korean Medicine, Dongguk University, Gyeongju, 38066, Korea
  4. College of Pharmacy, Seoul National University, Seoul, 08826, Korea
  
• 刊物主题：Pharmacy; Pharmacology/Toxicology;
• 出版者：Springer Netherlands
• ISSN：1976-3786

文摘

A new cytoprotective compound, 1-[(4S)-3,4-dihydro-4-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl]-ethanone (1) was isolated from the flower buds of Tussilago farfara L. (Compositae), together with eight known compounds, 3,4-dicaffeoyl isoquinic acid (2), trans-cinnamic acid (3), 4-hydroxyacetophenone (4), 4,5-dicaffeoylquinic acid methyl ester (5), 3,5-dicaffeoylquinic acid methyl ester (6), 4-hydroxybenzoic acid (7), isoquercetrin (8), and ligucyperonol (9). Compounds 2–4 were found in this plant for the first time. The isolates 1–9, were tested for their cytoprotective activities against glucose oxidase-induced oxidative stress in mouse fibroblast NIH3T3 cells and human keratinocyte HaCaT cells. Among them, 1 and 3 showed significant cytoprotective activities as determined by MTT assay and lactate dehydrogenase leakage, indicating their possibility as the potent cytoprotective agents. The structure of 1 was determined by spectroscopic data analysis including 1D- and 2D-NMR experiments, and its absolute configuration was elucidated by a circular dichroism.