Molecular pathways driving disease-specific alterations of intestinal epithelial cells
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- 作者：Rocío López-Posadas ; Markus F. Neurath ; Imke Atreya
- 关键词：Intestinal epithelial cells ; Inflammatory bowel diseases ; Colorectal cancer ; Colitis ; associated cancer ; Epithelial integrity
- 刊名：Cellular and Molecular Life Sciences
- 出版年：2017
- 出版时间：March 2017
- 年：2017
- 卷：74
- 期：5
- 页码：803-826
- 全文大小：
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Cell Biology; Biomedicine, general; Life Sciences, general; Biochemistry, general;
- 出版者：Springer International Publishing
- ISSN：1420-9071
- 卷排序：74
文摘
Due to the fact that chronic inflammation as well as tumorigenesis in the gut is crucially impacted by the fate of intestinal epithelial cells, our article provides a comprehensive overview of the composition, function, regulation and homeostasis of the gut epithelium. In particular, we focus on those aspects which were found to be altered in the context of inflammatory bowel diseases or colorectal cancer and also discuss potential molecular targets for a disease-specific therapeutic intervention.