Modulation of PKA, PKC, CAMKII, ERK 1/2 pathways is involved in the acute antidepressant-like effect of (octylseleno)-xylofuranoside (OSX) in mice

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• 作者：Lucimar M. Pinto Brod ; Mariana G. Fronza ; Jaqueline Pinto Vargas…
• 关键词：Organoselenium compounds ; Antidepressant activity ; Depression signalling pathways ; Tail suspension test
• 刊名：Psychopharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：234
• 期：4
• 页码：717-725
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Neurosciences; Pharmacology/Toxicology; Psychiatry;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-2072
• 卷排序：234

文摘

Rationale(Octylseleno)-xylofuranoside (OSX) is an organoselenium compound from the class of alkylseleno carbohydrates possessing a C8 alkyl chain. Members of this class of organoselenium compounds have promising pharmacological activities, among them are antioxidant and acute antidepressant-like activities with the involvement of monoaminergic system, as previously presented by our research group.