One-pot Reductive Amination of Carbonyl Compounds with NaBH 4 -B(OSO 3 H) 3 /SiO 2
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- 作者：HOSEIN HAMADI ; SAMIRA JAVADI
- 关键词：Reductive amination ; boron trisulfunic acid ; catalysis ; NaBH4.
- 刊名：Journal of Chemical Sciences
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：129
- 期：1
- 页码：75-80
- 全文大小：
- 刊物类别：Chemistry and Materials Science
- 刊物主题：Chemistry/Food Science, general;
- 出版者：Springer India
- ISSN：0973-7103
- 卷排序：129
文摘
An efficient one-pot procedure for the direct reductive amination of aldehyde and ketones was achieved in the presence of sodium borohydride by using B(OSO3H)3/SiO2(SBSA) as the reusable solid catalyst in acetonitrile and solvent-free conditions. Both aromatic and aliphatic aldehyde reacted well to give the corresponding amines in excellent yields. All the products are known and well-characterized. The catalyst is recoverable and could be easily recycled by filtration and reused several times without any significant loss of its activity. SBSA acts as a dual Brønsted/Lewis acid that is an air-stable and cost-effective solid acid.