Cell Motility and Cytoskeletal Regulation in Invasion and Metastasis
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- 作者：Dmitriy Kedrin ; Jacco van Rheenen ; Lorena Hernandez ; John Condeelis and Jeffrey E. Segall
- 关键词：Motility ; Chemotaxis ; Invasion ; Cytoskeleton ; Metastasis
- 刊名：Journal of Mammary Gland Biology and Neoplasia
- 出版年：2007
- 出版时间：September, 2007
- 年：2007
- 卷：12
- 期：2-3
- 页码：143-152
- 全文大小：350 KB
文摘
Cell motility and chemotaxis can make important contributions to the metastatic cascade. Cell migration pathways in general play significant roles in a variety of physiological processes that can be “hijacked” by cancer cells. Both growth factors and chemokines provide important chemotactic signals in development and metastasis. Receptor activation, following binding of a growth factor or a chemokine, leads to dynamic morphological changes in the actin cytoskeleton network via a variety of distinct and interconnected pathways, resulting in translocation of the cell up a chemoattractant gradient. Such gradients may be produced by stromal cells in the local microenvironment, including macrophages and fibroblasts. A better understanding of the mechanisms of cell motility and cytoskeletal regulation may provide novel therapeutic strategies that would block metastatic progression, reducing dissemination of tumor cells and increasing patient survival.