Semaphorins 4A and 4D in chronic inflammatory diseases

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• 作者：Svetlana P. Chapoval ; Zahava Vadasz ; Andrei I. Chapoval…
• 关键词：Semaphorins ; Chronic inflammation ; Asthma ; Autoimmune diseases ; Cancer
• 刊名：Inflammation Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：66
• 期：2
• 页码：111-117
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Immunology; Pharmacology/Toxicology; Rheumatology; Allergology; Dermatology; Neurology;
• 出版者：Springer International Publishing
• ISSN：1420-908X
• 卷排序：66

文摘

Long-term inflammatory processes directed at a particular endogenous or exogenous antigen, or sometimes of unknown etiology, form the pathogenetic basis for many debilitating conditions, such as cardiovascular, pulmonary, autoimmune, neurologic diseases, and cancer. Recent discoveries of neuroimmune semaphorins 4A and 4D (Sema4A and Sema4D, respectively) expression and function in the immune system and their key regulatory roles in fine tuning of inflammatory processes made them the molecules of interest for a potential immunotherapy. In this short review, we discuss the current knowledge in the Sema4A and Sema4D actions in chronic inflammation underlying the outlined above diseases.