Characterization of fortimicin aminoglycoside profiles produced from Micromonospora olivasterospora DSM 43868 by high-performance liquid chromatography-electrospray ionization-ion trap-mass spectrometry
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- 作者：Nguyen Lan Huong ; Nguyen Huu Hoang…
- 关键词：Fortimicin aminoglycosides ; Micromonospora olivasterospora ; HPLC ; ESI–ion trap–MS/MS ; Chiral column ; Pentafluoropropionic acid
- 刊名：Analytical and Bioanalytical Chemistry
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：408
- 期：6
- 页码：1667-1678
- 全文大小：1,106 KB
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Nguyen Huu Hoang (2)
Sung-Yong Hong (1)
Jae Kyung Sohng (2)
Yeo Joon Yoon (3)
Je Won Park (1)
2. Department of Biotechnology Convergent Pharmaceutical Engineering, SunMoon University, Chungnam, 336-708, Republic of Korea
1. School of Biosystem and Biomedical Science, Korea University, Seoul, 136-713, Republic of Korea
3. Department of Chemistry and Nano Sciences, Ewha Womans University, Seoul, 136-750, Republic of Korea - 刊物类别：Chemistry and Materials Science
- 刊物主题：Chemistry
Analytical Chemistry
Food Science
Inorganic Chemistry
Physical Chemistry
Monitoring, Environmental Analysis and Environmental Ecotoxicology - 出版者：Springer Berlin / Heidelberg
- ISSN：1618-2650
文摘
In this study, an efficient high-performance liquid chromatography (HPLC)-electrospray ionization (ESI)–ion trap-tandem mass spectrometry (MS/MS) was developed for the identification of the biosynthetic congeners involved in the aminocyclitol aminoglycosidic fortimicin pathway from Micromonospora olivasterospora fermentation. The usage of both acid extraction (pH ∼2.5) followed by an cationic-exchanging SPE cleanup and pentafluoropropionic acid mediated ion-pairing chromatography with ESI–ion trap–MS/MS detection was determined to be sufficiently practical to profile the fortimicin (FOR) congeners produced in a culture broth. The limit of the quantification for the fortimicin A (FOR-A) standard spiked in the culture broth was ∼1.6 ng mL−1. The average recovery rate was 93.6 %, and the intra- and inter-day precisions were <5 % with accuracy in the range from 87.1 to 94.2 %. Moreover, the epimeric mixtures including FOR-KH, FOR-KR, and FOR-B were separately resolved through a macrocyclic glycopeptide (teicoplanin)-bonded chiral column. As a result, ten natural FOR pseudodisaccharide analogs were identified and semi-quantified in descending order as follows: FOR-A, FOR-B, DCM, FOR-KH plus FOR-KR, FOR-KK1, FOR-AP, FOR-KL1, FOR-AO, and FOR-FU-10. This is the first report on both the simultaneous characterization of diverse structurally closely related FORs derived from bacterial fermentation using HPLC-ESI–ion trap–MS/MS analysis and the chromatographic separation of the three FOR epimers.