Mixed infections with distinct cytomegalovirus glycoprotein B genotypes in Polish pregnant women, fetuses, and newborns
详细信息 查看全文
- 作者：M. Rycel ; W. Wujcicka ; B. Zawilińska…
- 刊名：European Journal of Clinical Microbiology & Infectious Diseases
- 出版年：2015
- 出版时间：March 2015
- 年：2015
- 卷：34
- 期：3
- 页码：585-591
- 全文大小：291 KB
- 参考文献：1. Cannon, MJ (2009) Congenital cytomegalovirus (CMV) epidemiology and awareness. J Clin Virol 46: pp. S6-S10 CrossRef
2. Cordier, AG, Guitton, S, Vauloup-Fellous, C, Grangeot-Keros, L, Benachi, A, Picone, O (2012) Awareness and knowledge of congenital cytomegalovirus infection among health care providers in France. J Clin Virol 55: pp. 158-163 CrossRef
3. Gaj, Z, Rycel, M, Wilczyński, J, Nowakowska, D (2012) Seroprevalence of cytomegalovirus infection in the population of Polish pregnant women. Ginekol Pol 83: pp. 337-341
4. Paradowska, E, Studzińska, M, Nowakowska, D, Wilczyński, J, Rycel, M, Suski, P, Gaj, Z, Kaczmarek, B, Zbróg, Z, Le?nikowski, ZJ (2012) Distribution of UL144, US28 and UL55 genotypes in Polish newborns with congenital cytomegalovirus infections. Eur J Clin Microbiol Infect Dis 31: pp. 1335-1345 CrossRef
5. Syggelou, A, Iacovidou, N, Kloudas, S, Christoni, Z, Papaevangelou, V (2010) Congenital cytomegalovirus infection. Ann N Y Acad Sci 1205: pp. 144-147 CrossRef
6. Renzette, N, Bhattacharjee, B, Jensen, JD, Gibson, L, Kowalik, TF (2011) Extensive genome-wide variability of human cytomegalovirus in congenitally infected infants. PLoS Pathog 7: pp. e1001344 CrossRef
7. Arav-Boger, R, Foster, CB, Zong, JC, Pass, RF (2006) Human cytomegalovirus-encoded alpha -chemokines exhibit high sequence variability in congenitally infected newborns. J Infect Dis 193: pp. 788-791 CrossRef
8. Heo, J, Petheram, S, Demmler, G, Murph, JR, Adler, SP, Bale, J, Sparer, TE (2008) Polymorphisms within human cytomegalovirus chemokine (UL146/UL147) and cytokine receptor genes (UL144) are not predictive of sequelae in congenitally infected children. Virology 378: pp. 86-96 CrossRef
9. Ji, YH, Rong Sun, Z, Ruan, Q, Guo, JJ, He, R, Qi, Y, Ma, YP, Mao, ZQ, Huang, YJ (2006) Polymorphisms of human cytomegalovirus UL148A, UL148B, UL148C, UL148D genes in clinical strains. J Clin Virol 37: pp. 252-257 CrossRef
10. Navarro, D, Paz, P, Tugizov, S, Topp, K, Vail, J, Pereira, L (1993) Glycoprotein B of human cytomegalovirus promotes virion penetration into cells, transmission of infection from cell to cell, and fusion of infected cells. Virology 197: pp. 143-158 CrossRef
11. Pignatelli, S, Monte, MP, Rossini, G, Landini, MP (2004) Genetic polymorphisms among human cytomegalovirus (HCMV) wild-type strains. Rev Med Virol 14: pp. 383-410 CrossRef
12. Xanthakos, SA, Schleiss, MR (2003) Glycoprotein B genotyping of cytomegalovirus strains isolated in a pediatric population. Pediatr Infect Dis J 22: pp. 462-463
13. Spaete, RR, Saxena, A, Scott, PI, Song, GJ, Probert, WS, Britt, WJ, Gibson, W, Rasmussen, L, Pachl, C (1990) Sequence requirements for proteolytic processing of glycoprotein B of human cytomegalovirus strain Towne. J Virol 64: pp. 2922-2931
14. Zawilińska, B, Szostek, S, Kope?, J, Koprynia, M, Kosz-Vnenchak, M (2011) UL55 genotype diversity of cytomegalovirus strains isolated from newborns and infants hospitalized in southern Poland. Przegl Epidemiol 65: pp. 409-413
15. Paradowska, E, Jab?ońska, A, Studzińska, M, Suski, P, Kasztelewicz, B, Zawilińska, B, Wi?niewska-Ligier, M, Dzier?anowska-Fangrat, K, Wo?niakowska-G?sicka, T, Czech-Kowalska, J, Lipka, B, Kornacka, M, Pawlik, D, Tomasik, T, Kosz-Vnenchak, M, Le?nikowski, ZJ (2013) Distribution of cytomegalovirus gN variants and associated clinical sequelae in infants. J Clin Virol 58: pp. 271-275 CrossRef
16. Roubalová, K, Strunecky, O, Zufanová, S, Procházka, B, Vitek, A (2010) Genotyping of viral glycoprotein B (gB) in hematopoietic stem cell transplant recipients with active cytomegalovirus i - 刊物类别：Biomedical and Life Sciences
- 刊物主题：Biomedicine
Medical Microbiology
Internal Medicine - 出版者：Springer Berlin / Heidelberg
- ISSN：1435-4373
文摘
The purpose of this investigation was to describe a distribution of cytomegalovirus (CMV) single and multiple genotypes among infected pregnant women, their fetuses, and newborns coming from Central Poland, as well as congenital cytomegaly outcome. The study involved 278 CMV-seropositive pregnant women, of whom 192 were tested for viral DNAemia. Human cytomegalovirus (HCMV) genotyping was performed for 18 of 34 pregnant women carrying the viral DNA and for 12 of their 15 offspring with confirmed HCMV infections. Anti-HCMV antibodies levels were assessed by chemiluminescence immunoassay (CLIA) and enzyme-linked fluorescence assay (ELFA) tests. Viral DNA loads and genotypes were determined by real-time polymerase chain reaction (PCR) assays for the UL55 gene. In the pregnant women, we identified HCMV gB1, gB2, gB3, and gB4 genotypes. Single gB2, gB3, or gB4 genotypes were observed in 14 (77.8 %) women, while multiple gB1–gB2 or gB2–gB3 genotypes were observed in four (22.2 %). Maternal HCMV genotypes determined the genotypes identified in their fetuses and newborns (p?≤-.050). Half of them were infected with single HCMV gB1, gB2, or gB3 genotypes and the other half with multiple gB1–gB2 or gB2–gB3 genotypes. Single and multiple genotypes were observed in both asymptomatic and symptomatic congenital cytomegaly, although no gB3 genotype was identified among asymptomatic cases. In Central Poland, infections with single and multiple HCMV strains occur in pregnant women, as well as in their fetuses and neonates, with both asymptomatic and symptomatic infections. HCMV infections identified in mothers seem to be associated with the viral genotypes in their children.