A systematic approach to cancer: evolution beyond selection
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- 作者：William B. Miller Jr. ; John S. Torday
- 关键词：Cancer ; Self ; reference ; Information fields ; Hologenome ; Niche construction ; Stigmergy ; Aneuploidy ; Tissue ecology ; Cellular cognition ; Phenotype
- 刊名：Clinical and Translational Medicine
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：6
- 期：1
- 全文大小：1296KB
- 刊物主题：Medicine/Public Health, general;
- 出版者：Springer Berlin Heidelberg
- ISSN：2001-1326
- 卷排序：6
文摘
Cancer is typically scrutinized as a pathological process characterized by chromosomal aberrations and clonal expansion subject to stochastic Darwinian selection within adaptive cellular ecosystems. Cognition based evolution is suggested as an alternative approach to cancer development and progression in which neoplastic cells of differing karyotypes and cellular lineages are assessed as self-referential agencies with purposive participation within tissue microenvironments. As distinct self-aware entities, neoplastic cells occupy unique participant/observer status within tissue ecologies. In consequence, neoplastic proliferation by clonal lineages is enhanced by the advantaged utilization of ecological resources through flexible re-connection with progenitor evolutionary stages.