Connective tissue growth factor (CTGF) in the human dermis through ontogenesis

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• 作者：O. V. Vasilieva ; N. N. Golubtzova…
• 关键词：dermis ; ontogenesis ; fibroblasts ; blood vessels ; connective tissue growth factor
• 刊名：Russian Journal of Developmental Biology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：47
• 期：2
• 页码：63-68
• 全文大小：909 KB
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• 作者单位：O. V. Vasilieva (1)
  N. N. Golubtzova (1)
  F. N. Filippov (1)
  A. G. Gunin (1)
  
  1. Chuvash State University, Moscovskii pr. 15, Cheboksary, 428015, Russia
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Developmental Biology
  Animal Anatomy, Morphology and Histology
  Russian Library of Science
  
• 出版者：MAIK Nauka/Interperiodica distributed exclusively by Springer Science+Business Media LLC.
• ISSN：1608-3326

文摘

Connective tissue growth factor (CTGF) was examined in the structures of dermis of humans with different ages, from 20 weeks of pregnancy to 85 years. By immunohistochemistry, the fibroblasts and blood vessels positively stained for CTGF were observed in the dermis of all examined ages. An age-dependent increase in the percent of the fibroblasts and blood vessels positively stained for CTGF in the dermis was observed. A statistically significant negative correlation was found between the age-dependent changes in the total number of fibroblasts, percent of the fibroblasts with positive staining for proliferating cell nuclear antigen, and portion of the fibroblasts with positive staining for CTGF. Another statistically significant negative correlation was found between the age-dependent changes in the number of blood vessels and portion of the blood vessels with a positive staining for CTGF. The results suggest that CTGF has an inhibitory influence on the angiogenesis and fibroblast renewal in the human dermis through ontogenesis.