Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study

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• 作者：The InterAct Consortium (1)
• 关键词：Cohort studies – ; Diabetes mellitus – ; Epidemiologic research design – ; Gene– ; lifestyle interaction – ; Genetic epidemiology – ; Type 2 diabetes
• 刊名：Diabetologia
• 出版年：2011
• 出版时间：September 2011
• 年：2011
• 卷：54
• 期：9
• 页码：2272-2282
• 全文大小：285.0 KB
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• 作者单位：1. http://www.inter-act.eu
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Internal Medicine
  Metabolic Diseases
  Human Physiology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0428

文摘

Aims/hypothesis Studying gene–lifestyle interaction may help to identify lifestyle factors that modify genetic susceptibility and uncover genetic loci exerting important subgroup effects. Adequately powered studies with prospective, unbiased, standardised assessment of key behavioural factors for gene–lifestyle studies are lacking. This case–cohort study aims to investigate how genetic and potentially modifiable lifestyle and behavioural factors, particularly diet and physical activity, interact in their influence on the risk of developing type 2 diabetes.