The Yin and Yang of Wnt/Ryk axon guidance in development and regeneration

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• 作者：Charlotte E. J. Clark (1)
  Yaobo Liu (2)
  Helen M. Cooper (1)
  
• 关键词：Ryk ; Derailed ; Wnt ; Wnt signalling ; axon guidance ; axonal regeneration ; spinal cord injury
• 刊名：Science China Life Sciences
• 出版年：2014
• 出版时间：April 2014
• 年：2014
• 卷：57
• 期：4
• 页码：366-371
• 全文大小：
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• 作者单位：Charlotte E. J. Clark (1)
  Yaobo Liu (2)
  Helen M. Cooper (1)
  
  1. Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, 4072, Australia
  2. Institute of Neuroscience, Soochow University, Suzhou, 215123, China
  
• ISSN：1869-1889

文摘

In the developing embryo, nascent axons navigate towards their specific targets to establish the intricate network of axonal connections linking neurons within the mature nervous system. Molecular navigational systems comprising repulsive and attractive guidance cues form chemotactic gradients along the pathway of the exploring growth cone. Axon-bound receptors detect these gradients and determine the trajectory of the migrating growth cone. In contrast to their benevolent role in the developing nervous system, repulsive guidance receptors are detrimental to the axon’s ability to regenerate after injury in the adult. In this review we explore the essential and beneficial role played by the chemorepulsive Wnt receptor, Ryk/Derailed in axon navigation in the embryonic nervous system (the Yin function). Specifically, we focus on the role of Wnt5a/Rykmediated guidance in the establishment of two major axon tracts in the mammalian central nervous system, the corticospinal tract and the corpus callosum. Recent studies have also identified Ryk as a major suppressor of axonal regeneration after spinal cord injury. Thus, we also discuss this opposing aspect of Ryk function in axonal regeneration where its activity is a major impediment to axon regrowth (the Yang function).