Antiprotozoal and antimycobacterial activities of Persea americana seeds
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- 作者：Adelina Jiménez-Arellanes (1)
Julieta Luna-Herrera (2)
Ricardo Ruiz-Nicolás (2)
Jorge Cornejo-Garrido (1)
Amparo Tapia (3)
Lilián Yépez-Mulia (3) - 关键词：Medicinal plant ; Seeds ; Antimycobacterial ; Antiprotozoal ; Persea americana
- 刊名：BMC Complementary and Alternative Medicine
- 出版年：2013
- 出版时间：December 2013
- 年：2013
- 卷：13
- 期：1
- 全文大小：174KB
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34. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6882/13/109/prepub - 作者单位：Adelina Jiménez-Arellanes (1)
Julieta Luna-Herrera (2)
Ricardo Ruiz-Nicolás (2)
Jorge Cornejo-Garrido (1)
Amparo Tapia (3)
Lilián Yépez-Mulia (3)
1. Unidad de Investigación Médica en Farmacología (UIM), Hospital de Especialidades, CMNS XXI, Instituto Mexicano del Seguro Social (IMSS), Av. Cuauhtémoc 330, Col. Doctores, México, DF, 06720, Mexico
2. Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Plan de Ayala s/n, Col. Casco de Santo Tomás, México, DF, 11340, Mexico
3. UIM en Enfermedades Infecciosas y Parasitarias, Hospital de Pediatría, 2° piso, CMNS XXI, IMSS, Av. Cuauhtémoc 330, Col. Doctores, México, DF, 06720, Mexico
文摘
Background Persea americana seeds are widely used in traditional Mexican medicine to treat rheumatism, asthma, infectious processes as well as diarrhea and dysentery caused by intestinal parasites. Methods The chloroformic and ethanolic extracts of P. americana seeds were prepared by maceration and their amoebicidal, giardicidal and trichomonicidal activity was evaluated. These extracts were also tested against Mycobacterium tuberculosis H37Rv, four mono-resistant and two multidrug resistant strains of M. tuberculosis as well as five non tuberculosis mycobacterium strains by MABA assay. Results The chloroformic and ethanolic extracts of P. americana seeds showed significant activity against E. histolytica, G. lamblia and T. vaginalis (IC50 <0.634?μg/ml). The chloroformic extract inhibited the growth of M. tuberculosis H37Rv, M. tuberculosis MDR SIN 4 isolate, three M. tuberculosis H37Rv mono-resistant reference strains and four non tuberculosis mycobacteria (M. fortuitum, M. avium, M. smegmatis and M. absessus) showing MIC values ?0?μg/ml. Contrariwise, the ethanolic extract affected only the growth of two mono-resistant strains of M. tuberculosis H37Rv and M. smegmatis (MIC ?0?μg/ml). Conclusions The CHCl3 and EtOH seed extracts from P. americana showed amoebicidal and giardicidal activity. Importantly, the CHCl3 extract inhibited the growth of a MDR M. tuberculosis isolate and three out of four mono-resistant reference strains of M. tuberculosis H37Rv, showing a MIC--0?μg/ml. This extract was also active against the NTM strains, M. fortuitum, M. avium, M. smegmatis and M. abscessus, with MIC values <50?μg/ml.