Surveillance of testicular microlithiasis?: Results of an UK based national questionnaire survey

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• 作者：Subramanian Ravichandran (1) (4)
  Richard Smith (2)
  Philip A Cornford (3)
  Mark VP Fordham (3)
  
• 刊名：BMC Urology
• 出版年：2006
• 出版时间：December 2006
• 年：2006
• 卷：6
• 期：1
• 全文大小：456KB
• 参考文献：1. Doherty FJ, Mullins TL, Sant GR, Drinkwater MA, Ucci AA Jr: Testicular microlithiasis: A unique sonographic appearance. / J Ultrasound Med 1987,6(7):389-2.
  2. Winter TC 3rd, Zunkel DE, Mack LA: Testicular carcinoma in a patient with previously demonstrated testicular microlithiasis. / J Urol 1996,155(2):648. CrossRef
  3. Miller RL, Wissman R, White S, Ragosin R: Testicular microlithiasis: a benign condition with a malignant association. / J Clin Ultrasound 1996,24(4):197-02. CrossRef
  4. Kaveggia FF, Strassman MJ, Apfelbach GL, Hatch JL, Wirtanen GW: Diffuse testicular microlithiasis associated with intratubular germ cell neoplasia and seminoma. / Urology 1996,48(5):794-. CrossRef
  5. Parra BL, Venable DD, Gonzalez E, Eastham JA: Testicular microlithiasis as a predictor of intratubular germ cell neoplasia. / Urology 1996,48(5):797-. CrossRef
  6. Berger A, Brabrand K: Testicular microlithiasis a possibly premalignant condition: Report of five cases and a review of the literature. / Acta Radiol 1998,39(5):583-.
  7. Cast JE, Nelson WM, Early AS, Biyani S, Cooksey G, Warnock NG, Breen DJ: Testicular microlithiasis: prevalence and tumor risk in a population referred for scrotal sonography. / AJR Am J Roentgeno 2000,175(6):1703-.
  8. Backus ML, Mack LA, Middleton WD, King BF, Winter TC 3rd, True LD: Testicular microlithiasis: imaging appearances and pathologic correlation. / Radiology 1994,192(3):781-.
  9. Peterson AC, Bauman JM, Light DE, McMann LP, Costabile RA: The prevalence of testicular microlithiasis in an asymptomatic population of men 18 to 35 years old. / J Urol 2001,166(6):2061-. CrossRef
  10. Costabile RA: How worrisome is testicular microlithiasis? / State of the art lecture The AUA-2004 meeting at San Francisco
  11. Rashid HH, Cos LR, Weinberg E, Messing EM: Testicular microlithiasis: a review and its association with testicular cancer. / Urol Oncol 2004,22(4):285-.
  12. De Gouveia Brazao CA, Pierik FH, Oosterhuis JW, Dohle GR, Looijenga LH, Weber RF: Bilateral testicular microlithiasis predicts the presence of the precursor of testicular germ cell tumors in subfertile men. / J Urol 2004,171(1):158-0. CrossRef
  13. Holm M, Hoei-Hansen CE, Rajpert-De Meyts E, Skakkebaek NE: Increased risk of carcinoma in situ in patients with testicular germ cell cancer with ultrasonic microlithiasis in the contralateral testicle. / J Uro 2003,170(4 Pt 1):1163-. CrossRef
  14. Oiye T: Uber anscheinend noch nicht beschriebene Steinchen in den menschlichen Hoden. Beiter. / Path Anat 1928, 80:479.
  15. Blummensaat C: Ubereinen neuen Befund in Knabenhoden. / Virchows Arch Path Anat 1929, 273:51. CrossRef
  16. Bieger RC, Passarge E, Mcadams AJ: Testicular intratubular bodies. / J Clin Endocr 1965, 25:1340. CrossRef
  17. Azzopardi JG, Mostofi FK, Theiss EA: Lesions of testes observed in certain patients with widespread choriocarcinoma and related tumors. The significance and genesis of hematoxylin-staining bodies in the human testis. / Am J Pathol 1961, 38:207-5.
  18. Priebe CJ Jr, Garret R: Testicular calcification in a 4-year-old boy. / Pediatrics 1970,46(5):785-.
  19. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2490/6/8/prepub
  
• 作者单位：Subramanian Ravichandran (1) (4)
  Richard Smith (2)
  Philip A Cornford (3)
  Mark VP Fordham (3)
  
  1. Specialist Registrar in Urology, University Hospital Aintree, Liverpool, L9 7AL, UK
  4. 17, Milfield, Neston, Cheshire, CH64 3TF, UK
  2. SHO in Urology, Royal Liverpool University Hospital, Prescot Road, Liverpool, UK
  3. Consultant Urologist, Royal Liverpool University Hospital, Prescot Road, Liverpool, UK
  

文摘

Background The association of testicular microlithiasis with testicular tumour and the need for follow-up remain largely unclear. Methods We conducted a national questionnaire survey involving consultant BAUS members (BAUS is the official national organisation (like the AUA in USA) of the practising urologists in the UK and Ireland), to provide a snapshot of current attitudes towards investigation and surveillance of patients with testicular microlithiasis. Results Of the 464 questionnaires sent to the BAUS membership, 263(57%) were returned. 251 returns (12 were incomplete) were analysed, of whom 173(69%) do and 78(31%) do not follow-up testicular microlithiasis. Of the 173 who do follow-up, 119(69%) follow-up all patients while 54(31%) follow-up only a selected group of patients. 172 of 173 use ultra sound scan while 27(16%) check tumour makers. 10(6%) arrange ultrasound scan every six months, 151(88%) annually while 10(6%) at longer intervals. 66(38%) intend to follow-up these patients for life while, 80(47%) until 55 years of age and 26(15%) for up to 5 years. 173(68.9%) believe testicular microlithiasis is associated with CIS in < 1%, 53(21%) think it is between 1&10% while 7(3%) believe it is > 10%. 109(43%) believe those patients who develop a tumour, will have survival benefit with follow-up while 142(57%) do not. Interestingly, 66(38%) who follow-up these patients do not think there is a survival benefit. Conclusion There is significant variability in how patients with testicular microlithiasis are followed-up. However a majority of consultant urologists nationally, believe surveillance of this patient group confers no survival benefit. There is a clear need to clarify this issue in order to recommend a coherent surveillance policy.