Post-allogeneic Hematopoietic Stem Cell Transplantation (HSCT) changes in inorganic salivary components

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• 作者：C. C. Boer ; M. E. P. Correa ; L. M. A. Tenuta ; C. A. Souza…
• 关键词：Chronic graft ; versus ; host disease ; Hematopoietic stem cell transplantation ; Saliva ; Salivary gland dysfunction
• 刊名：Supportive Care in Cancer
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：23
• 期：9
• 页码：2561-2567
• 全文大小：611 KB
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  24.Hiroki A,
• 作者单位：C. C. Boer (1)
  M. E. P. Correa (1)
  L. M. A. Tenuta (2)
  C. A. Souza (1)
  A. C. Vigorito (1)
  
  1. Hematology and Blood Transfusion Center, University of Campinas, Rua Carlos Chagas, 480, P.O. Box: 6198, Campinas, SP, 13083-878, Brazil
  2. Department of Physiological Sciences, Piracicaba Dental School, University of Campinas - UNICAMP, Piracicaba, SP, Brazil
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  Nursing
  Nursing Management and Research
  Pain Medicine
  Rehabilitation Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1433-7339

文摘

Recent studies have considered the qualitative and quantitative assessment of salivary flow, as well the biochemical components of saliva, as possible biomarkers that might contribute to the pathogenesis of chronic graft-versus-host disease (cGHVD) in hematopoietic stem cell transplantation (HSCT) patients. The aim of this study was to evaluate prospectively the inorganic salivary status at different periods of allogeneic HSCT. Saliva collection and oral examination were performed prior?to the HSCT, ?between?days?8 and 10,?days?80 and 100, and at the cGVHD onset. Concentrations of calcium (Ca), phosphate (Pi), chloride (Cl), magnesium (Mg), potassium (K), and sodium (Na) were performed using colorimetric reactions and atomic absorption. Fifty-five consecutive patients undergoing first allogeneic HSCT were included in this study. Between days 8 and 10,?the salivary flow rate was significantly higher (p--.05), Pi concentration was decreased (p--.007), and Na and Cl were increased (p--.001 and?p--.001, respectively),?compared with the baseline. Salivary flow rate during the same period showed a negative correlation with Pi concentration (p--.02) and a positive correlation with Na and Cl concentrations (p--.003 and p--.001, respectively). The salivary flow rate was decreased between days 80 and 100 (p--.02) and Na, Cl, and K concentrations were increased (p--.03, p--.02, and p--.003, respectively). Salivary flow rate showed a negative correlation with Na and Cl (p--.01 and p--.013, respectively). At cGVHD onset, the salivary flow rate showed no statistical difference compared with the other studied periods. A trend was observed in the higher Na concentration compared with the baseline (p--.06) and Pi concentration presented a significant decrease (p--.004). Ca and Mg concentrations showed no changes during all evaluation periods. The present study showed changes in inorganic salivary components in post-HSCT periods, mainly during the early period post-HSCT and at the cGVHD onset. We speculate that Na, Cl, and Pi in saliva could be used as a potential biomarker in further studies.