The Role of ARV Associated Adverse Drug Reactions in Influencing Adherence Among HIV-Infected Individuals: A Systematic Review and Qualitative Meta-Synthesis

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• 作者：Haochu Li ; Gifty Marley ; Wei Ma ; Chongyi Wei ; Mellanye Lackey…
• 关键词：Adverse drug reaction ; Adherence ; Qualitative meta ; synthesis ; HIV ; Antiretroviral
• 刊名：AIDS and Behavior
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：21
• 期：2
• 页码：341-351
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Public Health; Health Psychology; Infectious Diseases;
• 出版者：Springer US
• ISSN：1573-3254
• 卷排序：21

文摘

Poor adherence remains a major barrier to achieving the clinical and public health benefits of antiretroviral drugs (ARVs). A systematic review and qualitative meta-synthesis was conduct to evaluate how ARV adverse drug reactions may influence ARV adherence. Thirty-nine articles were identified, and 33 reported that ARV adverse drug reactions decreased adherence and six studies found no influence. Visually noticeable adverse drug reactions and psychological adverse reactions were reported as more likely to cause non-adherence compared to other adverse drug reactions. Six studies reported a range of adverse reactions associated with EFV-containing regimens contributing to decreased adherence. Informing HIV-infected individuals about ARV adverse drug reactions prior to initiation, counselling about coping mechanisms, and experiencing the effectiveness of ARVs on wellbeing may improve ARV adherence.