Transition metal-promoted synthesis of 2-aryl/heteroaryl-thioquinazoline: C-S Bond formation by “Chan-Lam Cross-Coupling” Reaction
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- 作者：SATYA KARUNA PULAKHANDAM ; NARESH KUMAR KATARI…
- 关键词：Chan ; Lam coupling ; quinazoline ; boronic acids ; copper acetate
- 刊名：Journal of Chemical Sciences
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：129
- 期：2
- 页码：203-210
- 全文大小：
- 刊物类别：Chemistry and Materials Science
- 刊物主题：Chemistry/Food Science, general;
- 出版者：Springer India
- ISSN：0973-7103
- 卷排序：129
文摘
An efficient method for the synthesis of S-aryl /heteroaryl-quinazoline has been developed through the cross-coupling of 1,4-dihydroquinazoline with a variety of aryl and heteroaryl boronic acids assisted by [Cu(OAc) 2] as the catalyst for the formation of carbon-sulfur bonds. This newly developed method demonstrates that the conditions of the traditional copper-catalyzed Chan-Lam reaction can be improved. Optimized reaction involves base, solvent and catalyst.