Genetic dissection of gene regulation in multiple mouse tissues

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• 作者：Chris J. Cotsapas ; Rohan B.H. Williams ; Jeremy N. Pulvers ; David J. Nott ; Eva K.F. Chan ; Mark J. Cowley and Peter F.R. Little
• 刊名：Mammalian Genome
• 出版年：2006
• 出版时间：June 2006
• 年：2006
• 卷：17
• 期：6
• 页码：490-495
• 全文大小：99 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Cell Biology
  Anatomy
  Zoology
  
• 出版者：Springer New York
• ISSN：1432-1777

文摘

The analysis of the influence of genetic variation on regulation of gene expression at a near-genome-wide level has become the focus of much recent interest. It is widely appreciated that many genes are expressed in a tissue-specific manner and that others are more ubiquitously expressed but relatively little is known about how genetic variation might influence these tissue patterns of gene expression. In this review we discuss what is known about the tissue specificity of the influence of genetic variation and review the challenges that we face in combining hugely parallel, microarray-based gene analysis with equally expensive genetic analysis. We conclude that the available data suggest that genetic variation is essentially tissue specific in its effects upon gene expression and this has important implications for experimental analysis.