Salidroside Mitigates Sepsis-Induced Myocarditis in Rats by Regulating IGF-1/PI3K/Akt/GSK-3β Signaling

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• 作者：He He ; Xiayun Chang ; Jin Gao ; Lingpeng Zhu ; Mingxing Miao ; Tianhua Yan
• 关键词：salidroside ; sepsis ; myocardial inflammation ; IGF ; I/PI3K/Akt/GSK ; 3β signaling
• 刊名：Inflammation
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：38
• 期：6
• 页码：2178-2184
• 全文大小：947 KB
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• 作者单位：He He (1)
  Xiayun Chang (1)
  Jin Gao (1)
  Lingpeng Zhu (1)
  Mingxing Miao (1)
  Tianhua Yan (1)
  
  1. Department of Physiology and Pharmacology, China Pharmaceutical University, Tongjiaxiang 24, Nanjing, China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Rheumatology
  Internal Medicine
  Pharmacology and Toxicology
  Pathology
  
• 出版者：Springer Netherlands
• ISSN：1573-2576

文摘

Sepsis-induced myocardial injury (SIMI) is caused by various mechanisms. The aim of this study was to investigate the effects of salidroside (Sal) on SIMI and its mechanisms in rats. The sepsis model was established by intraperitoneal injection of lipopolysaccharide (LPS) (15 mg/kg in sterile saline). Sal decreased the serum levels of creatine kinase (CK), lactate dehydrogenase (LDH), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β), whereas the expressions of insulin-like growth factor-1 (IGF-1) signaling-related proteins, such as IGF-1 and its corresponding receptor (IGF-1R), phosphatidylinositol 3-kinase (PI3K), p-PI3K, Akt, p-Akt, and glycogen synthase kinase-3β (GSK-3β), in the heart were decreased with Sal pretreatment. Mitigated myocardial cell swelling, degeneration, loss of transverse striations, and inflammatory cell infiltration were also observed in the LPS-?Sal groups. Thus, Sal is assumed to exert pronounced cardioprotective effects in rats subjected to LPS, probably through regulation of IGF-1/PI3K/Akt/GSK-3β signaling. KEY WORDS salidroside sepsis myocardial inflammation IGF-I/PI3K/Akt/GSK-3β signaling