Mutational Analysis of the APC Gene in Cribriform-Morula Variant of Papillary Thyroid Carcinoma

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• 作者：Shinya Uchino ; Shiro Noguchi ; Hiroto Yamashita ; Hiroyuki Yamashita ; Shin Watanabe ; Takahiro Ogawa ; Akiko Tsuno ; Akiko Murakami and Akira Miyauchi
• 刊名：World Journal of Surgery
• 出版年：2006
• 出版时间：May 2006
• 年：2006
• 卷：30
• 期：5
• 页码：775-779
• 全文大小：178 KB

文摘

Introduction Familial adenomatous polyposis (FAP) is an inherited autosomal dominant syndrome caused by germline mutations in the adenomatous polyposis coli (APC) gene. Papillary thyroid cancer is one of the extracolonic manifestations of FAP. A characteristic histologic feature of this type of thyroid tumor is the cribriform-morula variant of papillary thyroid carcinoma (CMVPTC).