Sheep and goats as indicator animals for the circulation of CCHFV in the environment

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• 作者：Isolde Schuster ; Marc Mertens ; Slavcho Mrenoshki…
• 关键词：Crimean ; Congo hemorrhagic fever virus ; Southeastern Europe ; Ruminants ; Prevalence rate ; Risk area ; CCHF
• 刊名：Experimental and Applied Acarology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：68
• 期：3
• 页码：337-346
• 全文大小：361 KB
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• 作者单位：Isolde Schuster (1)
  Marc Mertens (1)
  Slavcho Mrenoshki (2)
  Christoph Staubach (3)
  Corinna Mertens (4)
  Franziska Brüning (1)
  Kerstin Wernike (5)
  Silke Hechinger (5)
  Kristaq Berxholi (6)
  Dine Mitrov (2)
  Martin H. Groschup (1)
  
  1. Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald, Isle of Riems, Germany
  2. Faculty of Veterinary Medicine, Saints Cyril and Methodius University in Skopje, Skopje, Macedonia
  3. Institute of Epidemiology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald, Isle of Riems, Germany
  4. Fachdienst Veterinärwesen und Verbraucherschutz, Landkreis Vorpommern-Rügen, Stralsund, Germany
  5. Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald, Isle of Riems, Germany
  6. Faculty of Veterinary Medicine in Tirana, Tirana, Albania
  
• 刊物主题：Entomology; Animal Systematics/Taxonomy/Biogeography; Animal Genetics and Genomics; Animal Ecology; Life Sciences, general;
• 出版者：Springer Netherlands
• ISSN：1572-9702

文摘

Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus, which causes a serious illness with case-fatality rates of up to 80 % in humans. CCHFV is endemic in many countries of Africa, Asia and Southeastern Europe. Next to the countries with endemic areas, the distribution of CCHFV is unknown in Southeastern Europe. As the antibody prevalence in animals is a good indicator for the presence or absence of the virus in a region, seroepidemiological studies can be used for the definition of risk areas for CCHFV. The aim of the present study was to reveal which ruminant species is best suited as indicator for the detection of a CCHFV circulation in an area. Therefore, the prevalence rates in sheep, goats and cattle in different regions of Albania and Former Yugoslav Republic of Macedonia were investigated. As there are no commercial tests available for the detection of CCHFV-specific antibodies in animals, two commercial tests for testing human sera were adapted for the investigation of sera from sheep and goats, and new in-house ELISAs were developed. The investigation of serum samples with these highly sensitive and specific assays (94–100 %) resulted in an overall prevalence rate of 23 % for Albania and of 49 % for Former Yugoslav Republic of Macedonia. Significant lower seroprevalence rates for CCHFV were found in cattle than in small ruminants in given areas. These results indicate that small ruminants are more suitable indicator animals for CCHFV infections and should therefore be tested preferentially, when risk areas are to be identified. Keywords Crimean-Congo hemorrhagic fever virus Southeastern Europe Ruminants Prevalence rate Risk area CCHF