Why do centenarians escape or postpone cancer? The role of IGF-1, inflammation and p53
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- 作者：Stefano Salvioli ; Miriam Capri ; Laura Bucci ; Cristina Lanni ; Marco Racchi ; Daniela Uberti ; Maurizio Memo ; Daniela Mari ; Stefano Govoni and Claudio Franceschi
- 关键词：Centenarians ; Cancer ; p53 ; IGF ; 1 ; Inflammation
- 刊名：Cancer Immunology, Immunotherapy
- 出版年：2009
- 出版时间：December, 2009
- 年：2009
- 卷：58
- 期：12
- 页码：1909-1917
- 全文大小：368.5 KB
文摘
Background Centenarians are exceptionally long living individuals who escaped the most common age-related diseases. In particular they appear to be effectively protected from cancers. The mechanisms that underlie this protection are quite complex and still largely unclear.