The serum levels of the cytokines involved in the Th17 and Th1 cell commitment are increased in individuals with borderline thrombocytopenia
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- 作者：Andreia Maria Camargos Rocha (1)
Cláudia Souza (2)
Gifone Aguiar Rocha (1)
Fabrício Freire de Melo (1) (3)
Nelma Cristina Diogo Clementino (2)
Marília Campos Abreu Marino (4)
Dulciene Maria Magalh?es Queiroz (1) - 关键词：Thrombocytopenia ; Th1 and Th17 cytokines ; IL2 ; 330 ; IL1RN VNTR
- 刊名：Journal of Hematology & Oncology
- 出版年：2013
- 出版时间：December 2013
- 年：2013
- 卷：6
- 期：1
- 全文大小：169KB
- 参考文献：1. Provan D, Stasi R, Newland AC, Blanchette VS, Bolton-Maggs P, Bussel JB, Chong BH, Cines DB, Gernsheimer TB, Godeau B, Grainger J, Greer I, Hunt BJ, Imbach PA, Lyons G, McMillan R, Rodeghiero F, Sanz MA, Tarantino M, Watson S, Young J, Kuter D: International consensus report on the investigation and management of primary immune thrombocytopenia. / Blood 2010, 115:168-86. CrossRef
2. Rodeghiero F, Stasi R, Gernsheimer T, Michel M, Provan D, Arnold DM, Bussel JB, Cines DB, Chong BH, Cooper N, Godeau B, Lechner K, Mazzucconi MG, McMillan R, Sanz MA, Imbach P, Blanchette V, Kühne T, Ruggeri M, George JN: Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report form an international working group. / Blood 2009, 113:2386-393. CrossRef
3. Stasi R, Amadori S, Osborn J, Newland AC, Provan D: Long-term outcome of otherwise healthy individuals with incidentally discovered borderline thrombocytopenia. / Plos Medicine 2006, 3:388-94.
4. Neunert C, Lim W, Crowther M, Cohen A, Solberg L Jr, Crowther MA: The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia. / Blood 2011, 117:4190-207. CrossRef
5. Grace RF, Long M, Kalish LA, Neufeld EJ: Applicability of 2009 international consensus terminology and criteria for immune thrombocytopenia to a clinical pediatric population. / Pediatr Blood Cancer 2012, 58:216-20. CrossRef
6. Rocha AMC, Souza C, Rocha GA, Melo FF, Clementino NCD, Marino MCA, Bozzi A, Silva ML, Martins-Filho OA, Queiroz DMM: The levels of IL-17A and of the cytokines involved in the Th17 cell commitment are increased in patients with chronic Immune Thrombocytopenia. / Haematologica 2011, 96:1560-564. CrossRef
7. Rocha AMC, Souza C, Rocha GA, Melo FF, Saraiva ISB, Clementino NCD, Marino MCA, Queiroz DMM: IL1RN VNTR and IL2 -330 polymorphic genes are independently associated with chronic immune thrombocytopenia. / Br J Haematol 2010, 150:679-84. CrossRef - 作者单位：Andreia Maria Camargos Rocha (1)
Cláudia Souza (2)
Gifone Aguiar Rocha (1)
Fabrício Freire de Melo (1) (3)
Nelma Cristina Diogo Clementino (2)
Marília Campos Abreu Marino (4)
Dulciene Maria Magalh?es Queiroz (1)
1. Laboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Av. Alfredo Balena, 190, sala 216, Belo Horizonte, 30130-100, Brazil
2. Hematology Service, University Hospital, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
3. Department of Microbiology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
4. Departament of Internal Medicine, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil - ISSN：1756-8722
文摘
The definition of immune Thrombocytopenia (ITP) as a peripheral blood platelet count less than 100 × 109/L instead of the historical criteria of 150 × 109/L renders subjects with platelets between 100 and 150 × 109/L without a diagnosis. Here, we demonstrated that these subjects have enhanced levels of proinflammatory cytokines linked to Th1 and Th17 cell response, and are more frequently carriers of polymorphisms in genes that code cytokines involved in the commitment of Th1 and Th17 immune response, when compared with controls, similarly to that observed in patients with ITP.