The Claim of Anti-Cataract Potential of Heliotropium indicum: A Myth or Reality?

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• 作者：Samuel Kyei ; George Asumeng Koffuor ; Paul Ramkissoon…
• 关键词：Alpha A and alpha B crystallins ; Aquaporin 0 ; Cataract ; DPPH scavenging effect
• 刊名：Ophthalmology and Therapy
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：4
• 期：2
• 页码：115-128
• 全文大小：1,161 KB
• 参考文献：1.Gurib-Fakim A. Heliotropium indicum L. In: Schmelzer GH, Gurib-Fakim A editors. Prota. 2006;11:(1) Medicinal plants/Plantes m茅dicinales 1. [CD-Rom]. PROTA, Wageningen.
  2.Pandey DP, Singh JP, Roy R, Singh VP, Pandey VB. Constituents of Heliotropium indicum. Orient J Chem. 1996;12:321鈥?.
  3.Mattocks AR. Minor alkaloids of H. indicum. J Chem Soc. 1967;15:329鈥?1.
  4. Mattocks AR, Schoental R, Crowley HC, Culvenor CCJ. 1064. Indicine: the major alkaloid of Heliotropium indicum L. J Chem Soc. 1961;5400鈥?403.
  5.Dutta SK, Sanyal U, Chakraborty SK. A modified method of isolation of Indicine-N-Oxide from H. indicum and its antitumor activity against ehrlich ascites carcinoma and sarcoma-180. Indian J Cancer Chem. 1987;9:73鈥?.
  6.Kugelman M, Liu WC, Axelrod M, Mc Bride TJ, Rao KV. Indicine-N-oxide: the antitumor principle of Heliotropium indicum. Lloydia. 1976;39:125.PubMed
  7.Birecka N, Frohlich MW, Glickman LM. Amino alcohols of pyrolizidine alkaloid in Heliotropium species. Part-4. Free and esterified necines in Heliotropium species from Mexico and Texas. Phytochemistry. 1983;22:1167鈥?1.CrossRef
  8.Rahmatullah M, Das AK, Mollik M, Jahan R, Khan M, Rahman T, et al. An ethnomedicinal survey of Dhamrai sub-district in Dhaka District, Bangladesh. Am Eurasian J Sustain Agric. 2009;3:881鈥?.
  9.Mollik MAH, Hossan MS, Paul AK, Rahman MT-U, Jahan R, Rahmatullah M. A comparative analysis of medicinal plants used by folk medicinal healers in three districts of Bangladesh and inquiry as to mode of selection of medicinal plants. Ethnobot Res Appl. 2010;8:195鈥?18.
  10.Baltussen R, Sylla M, Mariotti SP. Cost-effectiveness analysis of cataract surgery: a global and regional analysis. Bull World Health Organ. 2004;82:338鈥?5.PubMedCentral PubMed
  11.Mariotti SP. Global data on visual impairments 2010. World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland, 2012. WHO/NMH/PBD/12.01.
  12.Williamson E, Okpako DT, Evans FJ. Selection, preparation and pharmacological evaluation of plant material. Chichester: Wiley; 1996.
  13.Rates SMK. Plants as source of drugs. Toxicon. 2001;39:603鈥?3.CrossRef PubMed
  14.Harborne JB. Phytochemical methods: a guide to modern techniques of plant analysis. 3rd ed. London: Chapman and Hall; 1998.
  15.Kujur RS, Singh V, Ram M, Yadava HN, Singh KK, Kumari S, et al. Antidiabetic activity and phytochemical screening of crude extract of Stevia rebaudiana in alloxan-induced diabetic rats. Pharmacogn Res. 2010;2:258鈥?3.CrossRef
  16.Maloof AJ, Pandey SK, Neilson G, Milverton E. Selective death of lens epithelial cells using demineralized water and triton X-100 with perfect capsule sealed capsule irrigation: a histological study in rabbit eyes. Arch Ophthalmol. 2005;123:1378鈥?4.CrossRef PubMed
  17.Govindarajan R, Rastogi S, Vijayakumar M, Shirwaikar A, Rawat AK, Mehrotra S, et al. Studies on the antioxidant activities of Desmodium gangeticum. Biol Pharm Bull. 2003;26:1424鈥?.CrossRef PubMed
  18.Mitsuda H, Yuasumoto K, Iwami K. Antioxidation action of indole compounds during the autoxidation of linoleic acid. Eiyo to Shokuryo. 1996;19:210鈥?.CrossRef
  19.Kyselova Z. Different experimental approaches in modelling cataractogenesis: an overview of selenite-induced nuclear cataract in rats. Interdiscip Toxicol. 2010;3:3鈥?4.PubMedCentral CrossRef PubMed
  20.Cenedella RJ. Direct chemical measurement of DNA synthesis and net rates of differentiation of rat lens epithelial cells in vivo: applied to the selenium cataract. Exp Eye Res. 1987;44:677鈥?0.CrossRef PubMed
  21.Fris M, Tessem MB, Sather O, Midelfart A. Biochemical changes in selenite cataract model measured by high-resolution MAS (1)H NMR spectroscopy. Acta Ophthalmol Scand. 2006;84:684鈥?2.CrossRef PubMed
  22.Wang Z, Bunce GE, Hess JL. Selenite and Ca2+ homeostasis in the rat lens: effect on Ca-ATPase and passive Ca2+ transport. Curr Eye Res. 1993;12:213鈥?.CrossRef PubMed
  23.Duncan G, Webb SF, Dawson AP, Bootman MD, Elliott AJ. Calcium regulation in tissue-cultured human and bovine lens epithelial cells. Invest Ophthalmol Vis Sci. 1993;34:2835鈥?2.PubMed
  24.Duncan G, Williams MR, Raich RA. Calcium, cell signaling and cataract. Prog Ret Eye Res. 1994;13:623鈥?2.CrossRef
  25.Nakajima T, Nakajima E, Fukiage C, Azuma M, Shearer TR. Differential gene expression in the lens epithelial cells from selenite injected rats. Exp Eye Res. 2002;74:231鈥?.CrossRef PubMed
  26.Li WC, Kuszak JR, Dunn K, Wang RR, Ma W, Wang GM, et al. Lens epithelial cell apoptosis appears to be a common cellular basis for non-congenital cataract development in human and animals. J Cell Biol. 1995;130:169鈥?1.CrossRef PubMed
  27.Huang LL, Hess JL, Bunce GE. DNA damage, repair and replication in selenite-induced cataract in rat lens. Curr Eye Res. 1990;9:1041鈥?0.CrossRef PubMed
  28.Wang KKW, Nath R, Raser KJ, Hajimohammadreza I. Maitotoxin induces calpain activation in SH-SY5Y neuroblastoma cells and cerebrocortical cultures. Arch Biochem Biophys. 1996;331:208鈥?4.CrossRef PubMed
  29.David LL, Azuma M, Shearer TR. Cataract and the acceleration of calpain-induced 尾-crystallin insolubilization occurring during normal maturation of rat lens. Invest Ophthalmol Vis Sci. 1994;35:785鈥?3.PubMed
  30.Kupfer C. The conquest of cataract: a global challenge. Trans Ophthal Soc UK. 1984;104:1鈥?0.
  31.Harding JJ. Free and protein bound glutathione in normal and cataractous human lenses. Biochem J. 1970;117:957鈥?0.PubMedCentral CrossRef PubMed
  32.Nishigori H, Lee JW, Iwatsuru M. An animal model for cataract research: cataract formation in developing chick embryo by glucocorticoid. Exp Eye Res. 1983;36:617鈥?1.CrossRef PubMed
  33.Ansari NH, Srivastava SK. Role of glutathione in the prevention of cataractogenesis in rat lenses. Curr Eye Res. 1982;2:271鈥?.CrossRef PubMed
  34.Mostafapour MK, Reddy VN. Interactions of glutathione disulfide with lens crystallins. Curr Eye Res. 1982;2:591鈥?.CrossRef PubMed
  35.Jayakumar T, Thomas PA, Geraldine P. In-vitro antioxidant activities of an ethanolic extract of the oyster mushroom, Pleurotus ostreatus. Inn Food Sci Emerg Tech. 2009;10:228鈥?4.CrossRef
  36.Kamalakkannan N, Prince PS. The influence of rutin on the extracellular matrix in streptozotocin-induced diabetic rat kidney. J Pharm Pharmacol. 2006;58:1091鈥?.CrossRef PubMed
  37.Pragada RR, Rao Ethadi S, Yasodhara B, Praneeth Dasari VS, Mallikarjuna Rao T. In-vitro antioxidant and antibacterial activities of different fractions of Heliotropium indicum L. J Pharm Res. 2012;5(2):1051.
  38.Avarachan PJ, Rawal UM. Protein profile is the progressive experimental cataract (selenite model). Indian J Ophthalmol. 1985;33:303鈥?.PubMed
  39.Everett GA, Holley RW. Effect of minerals on amino acid incorporation by a rat liver preparation. Biochem Biophys Acta. 1961;46:390.CrossRef PubMed
  40.Petry JK. The effect of selenium (Se) on blood serum protein levels in occupational contact. Pregl Lek. 1970;26:552.
  41.Horwitz J. 伪 -Crystallin can function as a molecular chaperone. Proc Natl Acad Sci USA. 1992;89:10449鈥?3.PubMedCentral CrossRef PubMed
  42.Hook DWA, Harding JJ. Protection of enzymes by 伪-crystallin acting as a molecular chaperone. Int J Biol Macromol. 1988;22:295鈥?06.CrossRef
  43.Horwitz J, Bova MP, Ding LL, Haley DA, Stewart PL. Lens 伪-crystallin: function and structure. Eye. 1999;13:403鈥?.CrossRef PubMed
  44.Bloemendal H. Molecular and cellular biology of the eye lens. New York: Wiley; 1981.
  45.Horwitz J. Review alpha-crystallin. Exp Eye Res. 2003;2003(76):145鈥?3.CrossRef
  46.Mathias RT, Kistler J, Donaldson P. The lens circulation. J Membr Biol. 2007;216:1鈥?6.CrossRef PubMed
  47.Bloemendal H, Zweers A, Vermorken F, Dunia I, Benedetti EL. The plasma membranes of eye lens fibres. Biochemical and structural characterization. Cell Differ. 1972;1:91鈥?06.CrossRef PubMed
  48.Gonen T, Walz T. The structure of aquaporins. Q Rev Biophys. 2006;39:361鈥?6.CrossRef PubMed
  
• 作者单位：Samuel Kyei (1) (2)
  George Asumeng Koffuor (1) (3)
  Paul Ramkissoon (1)
  Clement Afari (4)
  Emmanuel Akomanin Asiamah (5)
  
  1. Discipline of Optometry, School of Health Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa
  2. Department of Optometry, School of Allied Health Sciences, College Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana
  3. Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
  4. Department of Optometry and Visual Sciences, College of Science, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
  5. Department of Pathology, Komfo Anokye Teaching Hospital, Kumasi, Ghana
  
• 刊物主题：Internal Medicine; Ophthalmology;
• 出版者：Springer Healthcare
• ISSN：2193-6528

文摘

Introduction Heliotropium indicum has several uses in traditional medicine attributable to its numerous bioactive compounds. It is used as a traditional remedy for cataracts in Ghana without any scientific verification. This study aimed at verifying the anti-cataract properties of an aqueous whole plant extract of H. indicum.