Disruption of clathrin-dependent trafficking results in the failure of grass carp reovirus cellular entry
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- 作者：Hao Wang ; Weisha Liu ; Fei Yu ; Liqun Lu
- 关键词：Ctenopharyngodon idellus ; Clathrin ; GCRV ; Ammonium chloride ; Viral entry
- 刊名：Virology Journal
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：13
- 期：1
- 全文大小：1,920 KB
- 刊物主题：Virology;
- 出版者：BioMed Central
- ISSN：1743-422X
文摘
Background Grass carp reovirus (GCRV) is responsible for viral hemorrhagic disease in cultured grass carp (Ctenopharyngon idellus). GCRV is a non-enveloped, double-stranded RNA virus in the genus Aquareovirus, of the family Reoviridae, which encodes seven structural proteins (VP1-VP7) and five nonstructural proteins (NS80, NS38, NS31, NS26, and NS16). To date, the mechanism of GCRV entry into CIK Ctenopharyngon idellus kidney (CIK) cells remains poorly understood.