Gli1, a potential regulator of esophageal cancer stem cell, is identified as an independent adverse prognostic factor in esophageal squamous cell carcinoma

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• 作者：Zhaoting Yang ; Yan Cui ; Weidong Ni…
• 关键词：Gli1 ; CSC ; Esophageal squamous cell carcinoma ; Biomarker
• 刊名：Journal of Cancer Research and Clinical Oncology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：143
• 期：2
• 页码：243-254
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Oncology; Cancer Research; Internal Medicine; Hematology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-1335
• 卷排序：143

文摘

Purpose The hedgehog (Hh) pathway is involved in cancer stem cell (CSC) maintenance in various tumors. Glioma-associated oncogene homolog 1 (Gli1) is a key mediator of the Hh pathway; however, its expression and clinical significance in esophageal squamous cell carcinoma (ESCC) have not been reported. In this study, we aimed to reveal clinical significance of Gli1 expression in ESCC and further investigate the potential of Gli1 as a CSC regulator of ESCC by comparing its expression with expressions of other stemness genes in ESCC.